Morphological features of anterior segment:factors influencing intraocular pressure after cataract surgery in nanophthalmos  

作　　者：Qiang Lu Wenwen He Yi Lu Xiangjia Zhu 

机构地区：[1]Department of Ophthalmology,Eye and Ear,Nose,and Throat Hospital,Fudan University,83Fenyang Road,Shanghai 200031,People'sRepublic of China [2]Eye Institute,Eye and Ear,Nose,and Throat Hospital of Fudan University,Shanghai 200031,People's Republic of China [3]Key Laboratory of Myopia,Ministryof Health,Shanghai200031,People's Republicof China [4]Shanghai Key Laboratory of Visual Impairment and Restoration,Shanghai 200031,People's Republic of China.

出　　处：《Eye and Vision》2023年第2期22-32,共11页眼视光学杂志（英文）

基　　金：funded by research grants from the National Natural Science Foundation of China(Grant Nos.81870642,81970780,81470613,81100653,81670835,and 81270989);the National Key R&D Program of China(Grant No.2018YFC0116800);the Outstanding Youth Medical Talents Program of the Shanghai Health and Family Planning Commission(Grant No.2017YQ011).

摘　　要：Purpose:To investigate the anterior segment in nanophthalmic eyes and their association with intraocular pressure after cataract surgery.Methods:Thirty-two nanophthalmic eyes(axial length[AL]<18.5 mm)in 18 patients and 35 normal eyes(21.0≤AL≤24.5 mm)in 35 controls who had undergone uneventful cataract surgery were included.Swept-source optical coherence tomography was used to compare the anterior segment structures between the two groups.The associations between the anterior segment characteristics of nanophthalmic eyes and postoperative intraocular pressure(IOP)were also investigated.Results:The IOP-lowering effect of cataract surgery was remarkably insufficient in nanophthalmic eyes.Peripheral anterior synechiae(PAS)were observed in 56%(18/32)of nanophthalmic eyes,and a characteristic boomerangshaped iris was observed in 28%(9/32).The anterior surface of the iris seemed"smoother"in nanophthalmic eyes than in normal eyes.Schlemm's canal(SC)diameter,SC area,trabecular meshwork(TM)thickness,TM width,and TM area were generally smaller in the nanophthalmic eyes.Younger age,higher preoperative IOP,broader PAS,and smaller SC area were main contributors to higher postoperative IOP.AL and SC diameter may also be of great importance in IOP prediction in patients without glaucoma surgery and PAS.Conclusions:The morphological features of the anterior segment in nanophthalmic eyes are significantly different from those of normal eyes.Influencing factors such as age,AL,preoperative IOP,extent of PAS,SC and TM size could all be prognostic for IOP after cataract surgery in nanophthalmic eyes.Trial registration:ClinicalTrails.gov,Trial registration number:NCT02182921,Registered 8 July 2014.

关 键 词：NANOPHTHALMOS Anterior segment Intraocular pressure Cataract surgery Peripheral anterior synechiae Boomerang-shaped iris Iris crypt Schlemm's canal Trabecular meshwork 

分 类 号：R776.1[医药卫生—眼科]