Investigation of corneal topographic and densitometric properties of Wilson's disease patients with or without a Kayser-Fleischer  

作　　者：Mehmet Fuat Alakus Mehtap Caglayan Nazim Ekin Hasan Oncul Esref Arac Umut Dag Halit Diri 

机构地区：[1]Department of Ophthalmology,University of Health Sciences,Diyarbakir Gazi Yasargil Research and Training Hospital,Diyarbakir,Turkey [2]Department of Internal Medicine,University of Health Sciences,Diyarbakir Gazi Yasargil Research and Training Hospital,Diyarbakir,Turkey.

出　　处：《Eye and Vision》2023年第2期33-40,共8页眼视光学杂志（英文）

摘　　要：Background:To investigate the topographic measurements and densitometry of corneas in Wilson's disease(WD)patients with or without a Kayser-Fleischer ring(KF-r)compared to healthy individuals.Methods:This cross-sectional study included 20 WD patients without a KF-r(group I),18 WD patients with a KF-r(groupⅠ),and 20 age-matched controls(group Ⅱ).The Pentacam high-resolution imaging system is used to determine corneal topographic measurements and densitometry.Results:Mean age for groups Ⅰ,Ⅱ and Ⅲ was 25.40±6.43 years(14-36 years),25.38±6.96 years(16-39 years),and 23.60±6.56 years(17-35 years),respectively(P=0.623).There was no significant difference between the groups in terms of the anterior corneal densitometry values(P>0.05),while the 6-10 mm and 10-12 mm midstroma and the 2-6 mm,6-10 mm,and 10-12 mm posterior corneal densitometry values in group Ⅱ were significantly higher than those in groups Ⅰ and Ⅱ(for all values,P<0.05).However,the 10-12 mm posterior corneal densitometry values in group Ⅰ were also significantly higher than those in group Ⅲ(P=0.038).The central corneal thickness(CCT),thinnest corneal thickness(tCT),and corneal volume(CV)values in groups Ⅰ and Ⅱ were significantly lower than those in group Ⅱ(for CCT values,P=0.011 and P=0.009;for tCT values,P=0.010 and P=0.005;for CV values,P=0.043 and P=0.029).Conclusion:In WD patients with a KF-r,corneal transparency decreased in the peripheral posterior and midstromal corneal layers;for these patients,corneal transparency may be impaired not only in the peripheral cornea but also in the paracentral cornea.

关 键 词：WILSON Kayser-Fleischer ring Corneal densitometry 

分 类 号：R772.2[医药卫生—眼科]