血清sCD105、Periostin、TK1在ⅢA-N2期非小细胞肺癌患者根治性切除术后复发中的临床应用价值研究  

Study on Clinical Application Value of Serum s CD105,Periostin and TK1in the Recurrence of Patients with Stage ⅢA-N2 Non-Small Cell Lung Cancer after Radical Resection

作　　者：郭军华 陈检明 宋志明 陈松林 易云峰 GUO Jun-hua;CHEN Jian-ming;SONG Zhi-ming;CHEN Song-lin;YI Yun-feng(Cardio-Thoracic Surgery,The 909th Hospital of Joint Logistics Support Force(Dongnan Hospital of Xiamen University)/Eastern Theater Cardiothoracic Surgery Medical Center,Zhangzhou,Fujian,363000,China)

机构地区：[1]中国人民解放军联勤保障部队第九〇九医院(厦门大学医学院附属东南医院)心胸外科/东部战区心胸外科医学中心,福建漳州363000

出　　处：《现代生物医学进展》2023年第6期1095-1099,共5页Progress in Modern Biomedicine

基　　金：全军后勤科研项目(CWH17J030;CNJ14C007)。

摘　　要：目的:探讨血清可溶性CD105(s CD105)、骨膜蛋白(Periostin)、胸苷激酶1(TK1)对ⅢA-N2期非小细胞肺癌(NSCLC)患者根治性切除术后复发风险的预测价值。方法:选取2017年1月~2019年5月我院收治的127例接受根治性切除术的ⅢA-N2期NSCLC患者,根据术后3年是否复发分为复发组64例和无复发组63例,收集患者临床资料并采用酶联免疫吸附法检测血清s CD105、Periostin、TK1水平。通过多因素Logistic回归分析ⅢA-N2期NSCLC根治性切除术后复发的影响因素,受试者工作特征(ROC)曲线分析血清s CD105、Periostin、TK1水平对ⅢA-N2期NSCLC患者根治性切除术后复发的预测价值。结果:复发组血清s CD105、Periostin、TK1水平高于无复发组(P<0.05)。复发组纵膈淋巴结转移数、隆突下淋巴结转移数、N2多站转移、N2多区域转移、N2跨区域转移比例高于无复发组(P<0.05)。多因素Logistic回归分析显示,纵膈淋巴结转移数增加、N2跨区域转移和s CD105升高、Periostin升高、TK1升高为ⅢA-N2期NSCLC根治性切除术后复发的独立危险因素(P<0.05)。ROC曲线分析显示,血清s CD105、Periostin、TK1单独与联合预测ⅢA-N2期NSCLC根治性切除术后复发的曲线下面积分别为0.788、0.771、0.787、0.917,三项联合预测的曲线下面积大于各指标单独预测。结论:血清s CD105、Periostin、TK1水平升高为ⅢA-N2期NSCLC患者根治性切除术后复发的独立危险因素,联合检测血清s CD105、Periostin、TK1对ⅢA-N2期NSCLC患者根治性切除术后复发的预测价值较高。Objective:To investigate the predictive value of serum soluble CD105(sCD105),Periostin and thymidine kinase 1(TK1)on the risk of recurrence of patients with stage IIIA-N2 non-small cell lung cancer(NSCLC)after radical resection.Methods:127 patients with stage IIIA-N2 NSCLC who underwent radical resection in our hospital from January 2017 to May 2019 were selected,and they were divided into recurrence group with 64 cases and non-recurrence group with 63 cases according to whether there was recurrence 3 years after surgery.The clinical data of the patients were collected and the levels of serum sCD105,Periostin and TK1 were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of recurrence of stage IIIA-N2 NSCLC after radical resection.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of the levels of serum sCD105,Periostin and TK1 in patients with stage IIIA-N2 NSCLC after radical resection.Results:The levels of serum sCD105,Periostin and TK1 in the recurrence group were higher than those in the non-recurrence group(P<0.05).The number of mediastinal lymph node metastasis,number of subcarinal lymph node metastasis,N2 multi-station metastasis,N2 multi-regional metastasis and N2 cross-regional metastasis ratio in the recurrence group were higher than those in the non-recurrence group(P<0.05).Multivariate Logistic regression analysis showed that increased number of mediastinal lymph node metastasis,N2 cross-regional metastasis and elevated sCD105,elevated Periostin and elevated TK1 were independent risk factors for recurrence of stageⅢA-N2 NSCLC after radical resection(P<0.05).ROC curve analysis showed that the area under the curve of serum sCD105,Periostin and TK1 in predicting the recurrence of stageⅢA-N2 NSCLC after radical resection were 0.788,0.771,0.787 and 0.917 respectively,the area under the curve of the combined prediction of the three indexes was greater than that of each index alone. Conclusion: Ele

关 键 词：非小细胞肺癌 根治性切除术 复发 s CD105 PERIOSTIN TK1 预测价值 

分 类 号：R734.2[医药卫生—肿瘤]