唑来膦酸联合同期放化疗治疗晚期乳腺癌合并骨转移的临床效果与血清钙、VEGF水平观察  

Clinical effect and serum calcium and VEGF levels of zoledronic acid combined with concurrent chemoradiotherapy in the treatment of advanced breast cancer with bone metastases

作　　者：李强[1] 许俊磊 屈忠 Li Qiang;Xu Junlei;Qu Zhong(Changsha Central Hospital Affiliated to Nanhua University,Changsha,Hunan 410004,China)

机构地区：[1]南华大学附属长沙中心医院,湖南长沙410004

出　　处：《首都食品与医药》2023年第9期65-67,共3页Capital Food Medicine

摘　　要：目的探究应用唑来膦酸联合同期放化疗治疗对改善晚期乳腺癌合并骨转移的临床效果以及对血清钙、VEGF水平的影响。方法研究对象来自南华大学附属长沙中心医院,所有患者均采用计算机随机分组,60例晚期乳腺癌合并骨转移患者被平均分为观察组(n=30)和对照组(n=30),前者应用唑来膦酸联合同期放化疗治疗,后者应用同期放化疗治疗,实施时间为2021年1月-2022年1月。将两组患者的临床效果、血清钙、VEGF水平、生活质量(QLQ-BR53)评分以及药物不良反应进行比较。结果在治疗总有效率控制方面,两组数据差异很大,观察组、对照组分别为76.67%、56.67%(P<0.05);治疗前,将两组的血清钙、VEGF水平进行分析,得出两组的数据较为相似(P>0.05);治疗6个周期后,该两项指标显著下降且观察组低于对照组(P<0.05);治疗前,将两组的各项QLQ-BR53评分进行分析,得出两组的数据较为相似(P>0.05);治疗6个周期后,观察组各项QLQ-BR53评分显著高于对照组(P<0.05);在并发症发生率控制方面,两组数据差异不大,观察组、对照组分别为13.33%、16.67%(P>0.05)。结论为改善晚期乳腺癌合并骨转移的临床效果与血清钙、VEGF水平,选择应用唑来膦酸联合同期放化疗治疗具有明显效果,药物不良反应较少,患者预后得到提升。Objective To explore the clinical effect and serum calcium and VEGF levels of advanced breast cancer complicated with bone metastasis,zoledronic acid combined with concurrent chemoradiotherapy was selected for treatment.Methods All patients in our hospital were randomly divided by computer.60 patients with advanced breast cancer complicated with bone metastasis were divided into observation group(n=30)and control group(n=30).The former group was treated with zoledronic acid combined with concurrent chemoradiotherapy,and the latter group was treated with concurrent chemoradiotherapy from January 2021 to January 2022.The clinical effects,serum calcium,VEGF levels,quality of life(QLQ-BR53)scores and adverse drug reactions were compared between the two groups.Results In terms of total effective rate control,there were significant differences between the two groups,which were 76.67%in the observation group and 56.67%in the control group(P<0.05).compared with the control group,the serum calcium and VEGF levels of the observation group were analyzed before treatment,and the data of the two groups were similar(P>0.05).After 6 cycles of treatment,the two indexes of the former were significantly decreased(P<0.05);compared with the control group,QLQ-BR53 scores of the observation group were analyzed before treatment,and the data of the two groups were similar(P>0.05).After 6 cycles of treatment,the QLQ-BR53 scores in the observation group were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups,which were 1333%in the observation group and 16.67%in the control group(P>0.05).Conelusions In order to improve the clinical effect and serum calcium and VEGF levels of advanced breast cancer complicated with bone metastasis,zoledronic acid combined with concurrent chemoradiotherapy has obvious effect,less adverse drug reactions and improved prognosis of patients.

关 键 词：晚期乳腺癌 同期放化疗 唑来膦酸 骨转移 血清钙 VEGF水平 

分 类 号：R737.9[医药卫生—肿瘤]