NLR联合血清CA15-3、NGF、BSP对三阴性乳腺癌患者术后发生骨转移的预测价值  

Predictive value of NLR combined with serum CA15-3,NGF and BSP on the occurrence risk of bone metastasis in triple negative breast cancer patients after operation

作　　者：单世胜 王华龙 王飞 王健雄 王冰 SHAN Shisheng;WANG Hualong;WANG Fei;WANG Jianxiong;WANG Bing(Department of Thyroid and Breast Surgery,Xianyang Central Hospital,Xianyang,Shaanxi 712000,China)

机构地区：[1]陕西省咸阳市中心医院甲乳外科,陕西咸阳712000

出　　处：《检验医学与临床》2023年第10期1369-1373,共5页Laboratory Medicine and Clinic

基　　金：陕西省卫生健康科研项目(2018C0367)。

摘　　要：目的探讨中性粒细胞/淋巴细胞比值(NLR)联合血清糖类抗原15-3(CA15-3)、神经生长因子(NGF)、骨唾液酸蛋白(BSP)对三阴性乳腺癌患者术后发生骨转移的预测价值。方法选择2017年2月至2020年3月该院收治并进行手术治疗的三阴性乳腺癌患者132例为研究对象,术后随访24个月,根据患者是否出现骨转移分为骨转移组和无骨转移组。比较两组术前NLR及血清CA15-3、NGF、BSP水平,纳入临床资料,采用多因素Logistic回归分析三阴性乳腺癌患者术后发生骨转移的危险因素及建立回归预测模型,采用受试者工作特征(ROC)曲线分析NLR联合血清CA15-3、NGF、BSP对三阴性乳腺癌患者术后发生骨转移的预测价值。结果术后随访24个月,根据患者是否出现骨转移分为骨转移组28例和无骨转移组104例。骨转移组术前NLR、CA15-3、NGF、BSP水平明显高于无骨转移组,差异有统计学意义(P<0.05)。骨转移组有淋巴结转移、TNM分期Ⅲ期比例高于无骨转移组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,NLR、CA15-3、NGF、BSP水平升高及有淋巴结转移是三阴性乳腺癌患者术后发生骨转移的危险因素(P<0.05)。ROC曲线分析结果显示NLR联合血清CA15-3、NGF、BSP预测三阴性乳腺癌患者术后发生骨转移的曲线下面积最大,为0.828。结论三阴性乳腺癌术后发生骨转移患者的术前NLR、CA15-3、NGF、BSP水平升高,4项指标联合对三阴性乳腺癌患者术后发生骨转移具有较高的预测价值。Objective To explore the predictive value of neutrophil/lymphocyte ratio(NLR)combined with serum carbohydrate antigen 15-3(CA15-3),nerve growth factor(NGF)and bone sialoprotein(BSP)on the occurrence risk of bone metastasis in triple negative breast cancer patients after operation.Methods A total of 132 cases of triple negative breast cancer patients who underwent surgical treatment in Xianyang Central Hospital from February 2017 to March 2020 were selected.The patients were followed up for 24 months after operation,according to whether the patients had bone metastasis or not,they were divided into bone metastasis group and non-bone metastasis group.The preoperative NLR,serum CA15-3,NGF and BSP levels were compared between the two groups,and the clinical data were included.Multivariate Logistic regression was used to analysis the risk factors of bone metastasis in triple negative breast cancer patients after operation and establish the regression prediction model.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of NLR combined with serum CA15-3,NGF and BSP on the occurrence risk of bone metastasis in triple negative breast cancer patients after operation.Results The patients were followed up for 24 months after operation,according to whether the patients had bone metastasis or not,they were divided into bone metastasis group with 28 cases and non-bone metastasis group with 104 cases.The preoperative NLR,CA15-3,NGF and BSP levels in the bone metastasis group were significantly higher than those in the non-bone metastasis group(P<0.05).The proportion of lymph node metastasis and TNM stageⅢin the bone metastasis group were higher than those in the non-bone metastasis group(P<0.05).Multivariate Logistic regression analysis showed that increased NLR,CA15-3,NGF,BSP levels,lymph node metastasis were risk factors for postoperative bone metastasis in triple negative breast cancer patients(P<0.05).ROC curve analysis showed that the area under the curve of NLR combined with serum CA1

关 键 词：三阴性乳腺癌 骨转移 中性粒细胞/淋巴细胞比值 糖类抗原15-3 神经生长因子 骨唾液酸蛋白 

分 类 号：R737.9[医药卫生—肿瘤]