分化型甲状腺腺癌患者血清ADPN、adipoR2和HSP70水平的临床意义  

Clinical value of serum ADPN,adipoR2 and HSP70 levels in differentiated thyroid adenocarcinoma

作　　者：熊睿 殷剑光 王华 XIONG Rui;YIN Jianguang;WANG Hua(Department of General Surgery,Jiangqiao Hospital of Jiading District/Jiading Branch of Shanghai First People′s Hospital,Shanghai 201803,China)

机构地区：[1]上海市嘉定区江桥医院/上海市第一人民医院嘉定分院普外科,上海201803

出　　处：《检验医学与临床》2023年第10期1422-1426,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血清脂联素(ADPN)、脂联素受体2(adipoR2)和热休克蛋白70(HSP70)检测在分化型甲状腺腺癌中的临床价值。方法选择2020年8月至2022年6月在上海市嘉定区江桥医院/上海市第一人民医院嘉定分院进行手术治疗的甲状腺腺癌患者75例为甲状腺腺癌组。选择同期在上海市嘉定区江桥医院/上海市第一人民医院嘉定分院诊断为甲状腺腺瘤的患者和健康体检者分别纳入甲状腺腺瘤组(65例)和对照组(45例)。比较甲状腺腺癌组(术前)与甲状腺腺瘤组、对照组,以及甲状腺腺癌组术前与术后血清ADPN、adipoR2和HSP70水平。分析3项指标之间的相关性,以及血清ADPN、adipoR2和HSP70对甲状腺腺癌的临床诊断价值及其与临床病理特征的关系。结果甲状腺腺癌组(术前)血清ADPN和adipoR2水平明显低于甲状腺腺瘤组和对照组,而甲状腺腺瘤组明显低于对照组,差异有统计学意义(P<0.05);而甲状腺腺癌组(术前)血清HSP70水平明显高于甲状腺腺瘤组和对照组,甲状腺腺瘤组明显高于对照组,差异有统计学意义(P<0.05)。血清ADPN、adipoR2和HSP70联合检测诊断甲状腺腺癌的灵敏度为85.3%,特异度为83.1%,曲线下面积(AUC)为0.906,AUC明显高于ADPN(Z=4.391,P<0.001)、adipoR2(Z=3.253,P<0.001)和HSP70(Z=3.795,P<0.001)单独检测,而3项指标单独检测的AUC比较,差异无统计学意义(P>0.05)。不同肿瘤最大径、淋巴结转移情况和TNM分期的甲状腺腺癌患者ADPN、adipoR2、HSP70水平比较,差异有统计学意义(P<0.05)。不同年龄、性别的甲状腺腺癌患者血清ADPN、adipoR2和HSP70水平比较,差异无统计学意义(P>0.05)。结论血清ADPN、adipoR2和HSP70水平参与了甲状腺腺癌的发生、发展过程,联合检测ADPN、adipoR2和HSP70有助于提高甲状腺腺癌的诊断效能。Objective To investigate the clinical value of serum adiponectin(ADPN),adiponectin receptor 2(adipoR2)and heat shock protein 70(HSP70)levels in differentiated thyroid adenocarcinoma.Methods A total of 75 patients with thyroid adenocarcinoma who underwent surgery in Jiangqiao Hospital of Jiading District/Jiading Branch of Shanghai First People′s Hospital from August 2020 to June 2022 were selected as the thyroid adenocarcinoma group.Patients diagnosed with thyroid adenoma in the same period and healthy physical examination subjects were selected as thyroid adenoma group(65 cases)and control group(45 cases)respectively.The serum levels of ADPN,adipoR2 and HSP70 were compared among the thyroid adenocarcinoma group,thyroid adenoma group and control group,and the thyroid adenocarcinoma group before and after surgery.To analyze the correlations among the three indexes,as well as the clinical diagnostic value of serum ADPN,adipoR2 and HSP70 in thyroid adenocarcinoma and their relationships with clinicopathological factors.Results The serum ADPN and adipoR2 levels in thyroid adenocarcinoma group before surgery were significantly lower than those in thyroid adenoma group and control group,while those in thyroid adenoma group were significantly lower than those in control group,the differences were statistically significant(P<0.05).The serum HSP70 level in thyroid adenocarcinoma group(hefore operation)was significantly higher than that in thyroid adenoma group and control group,and the serum HSP70 level in thyroid adenoma group was significantly higher than that in control group,the differences were statistically significant(P<0.05).The sensitivity and specificity of serum ADPN,adipoR2 and HSP70 in the diagnosis of thyroid adenocarcinoma were 85.3%,83.1%,and the area under curve(AUC)was 0.906,the AUC was significantly higher than that of ADPN(Z=4.391,P<0.001),adipoR2(Z=3.253,P<0.001)and HSP70(Z=3.795,P<0.001),but there was no significant difference on AUC among the three indexes(P>0.05).There were statistically significa

关 键 词：脂联素 脂联素受体2 热休克蛋白70 甲状腺腺癌 

分 类 号：R736.1[医药卫生—肿瘤]