探讨抗阻力运动联合营养干预对老年衰弱的疗效及机制  

Explore the Therapeutic Effect and Mechanism of Anti Resistance Exercise Combined With Nutritional Intervention on Senile Asthenia

作　　者：张碧琴 陈家秀[1] 韩海燕[1] 张立欣[1] ZHANG Biqin;CHEN Jiaxiu;HAN Haiyan;ZHANG Lixin(Department of Gerontology,the First Hospital of Fuzhou City,Fujian Province,Fuzhou Fujian 350009,China)

机构地区：[1]福建省福州市第一医院老年科,福建福州350009

出　　处：《中国卫生标准管理》2023年第8期100-104,共5页China Health Standard Management

基　　金：2021年福建省福州市科技计划项目(2021-S-183)。

摘　　要：目的探讨基于NLRP3炎性小体分析老年衰弱患者接受抗阻力运动及营养干预对改善其衰弱状态所发挥的作用。方法随机选取2021年7月—2022年10月在福建省福州市第一医院进行治疗的老年衰弱患者100例,并经随机数字表法将患者分为两组。对照组(n=50)患者给予常规干预,观察组在对照组干预基础上给予(n=50)患者抗阻力运动联合营养干预,对比干预前后两组患者的NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermoprotein domain-related protein 3,NLRP3)、胱氨酸蛋白酶-1信使核糖核酸(cysteine protease-1 messenger RNA,caspase-1 mRNA)的表达水平及白细胞介素-1β(Interleukin-1β,IL-1β)、白细胞介素-18(Interleukin-18,IL-18)水平,对比干预前后患者活动量减少、疲乏明显、步速下降、体质量下降、握力下降等衰弱指标改善效果。结果干预前两组患者NLRP3、capase-1表达水平及IL-1β、IL-18水平差异无统计学意义(P>0.05),干预后观察组患者NLRP3、capase-1表达水平及IL-1β、IL-18水平均低于对照组,差异有统计学意义(P<0.05)。干预后观察组患者各项衰弱指标改善情况明显优于对照组,差异有统计学意义(P<0.05)。结论老年衰弱患者NLRP3、caspase-1 mRNA的表达水平及IL-1β、IL-18水平较高,为患者提供抗阻力运动及营养干预有助于降低患者NLRP3炎性小体水平,能够使患者炎性因子水平及衰弱指标得到有效改善,对于延缓其衰老进程有重要作用。Objective To explore the role of anti resistance exercise intervention and nutritional intervention in improving the aging state of debilitating elderly patients based on the analysis of NLRP3 inflammatory bodies.Methods A total of 100 elderly patients with asthenia who were treated in the First Hospital of Fuzhou City,Fujian Province from July 2021 to October 2022 were randomLy selected and divided into two groups by random number table method.The patients in the control group(n=50)were given routine intervention.On the basis of the intervention in the control group,the patients in the observation group(n=50)were given resistance exercise combined with nutritional intervention.The expression levels of NOD-like receptor heat protein domain related protein 3(NLRP3),Cystine-1 messenger RNA(caspase-1 mRNA),Interleukin-1β、IL-1β、and Interleukin-18(IL-18)levels before and after intervention were compared.Results Before the intervention,there was no significant difference in the expression levels of NLRP3,capase-1 and IL-1βand IL-18 between the two groups(P>0.05).After the intervention,the expression levels of NLRP3,capase-1,IL-1βand IL-18 in the observation group were lower than those in the control group,and the difference between the two groups was statistically significant(P<0.05).After the intervention,the improvement of various debilitating indexes in the observation group was obviously better than that in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion The expression level of NLRP3 and caspase-1 mRNA and IL-1 in senile patients with astheniaβ,the level of IL-18 is high.Providing patients with anti resistance exercise and nutritional intervention can help reduce the level of NLRP3 inflammatory corpuscles,effectively improve the patients'asthenia indicators,and play an important role in delaying the aging process.

关 键 词：老年衰弱 NLRP3炎性小体 抗阻力运动 营养干预 衰弱指标 炎性因子 

分 类 号：R364[医药卫生—病理学]