^(99)Tc^(m)-3PRGD_(2)SPECT显像临床应用进展  

Progresses in clinical application of^(99)Tc^(m)-3PRGD_(2) SPECT imaging

作　　者：母昌洁 张卫方[1] 彭彤 赵梅莘[1] MU Changjie;ZHANG Weifang;PENG Tong;ZHAO Meixin(Department of Nuclear Medicine,Peking University Third Hospital,Beijing 100191,China;Department of Nuclear Medicine,the First People's Hospital of Bijie City,Bijie 551700,China)

机构地区：[1]北京大学第三医院核医学科,北京100191 [2]毕节市第一人民医院核医学科,贵州毕节551700

出　　处：《中国医学影像技术》2023年第5期777-780,共4页Chinese Journal of Medical Imaging Technology

基　　金：北京大学第三医院临床重点项目(BYSYZD2019038)。

摘　　要：整合素在肿瘤血管生成及转移中起着重要作用。精氨酸-甘氨酸-天冬氨酸(RGD)能够与整合素α_(v)β_(3)亚型特异性结合。以RGD为基础开发的SPECT显像剂——^(99)Tc^(m)-联肼尼克酰胺-3聚乙二醇-精氨酸-甘氨酸-天冬氨酸环肽二聚体(^(99)Tc^(m)-3PRGD_(2))可与细胞表面的整合素α_(v)β_(3)受体相结合,主要用于诊断肿瘤和评估疗效等。本文就^(99)Tc^(m)-3PRGD_(2)显像临床应用进展进行综述。Integrins play an important role in tumor angiogenesis.Arg-Gly-Asp(RGD)can specifically bind integrinαvβ3.As a SPECT imaging tracer,^(99)Tc^(m)-3polyethylene glycol-arginine-glycine-aspartic acid(^(99)Tc^(m)-3PRGD_(2))was designed based on RGD,which could bind to integrinαvβ3 receptor on cell,having be applicated mainly in diagnosis and evaluation on therapeutic efficacy of tumors.The progresses of^(99)Tc^(m)-3PRGD_(2) in clinical application were reviewed in this article.

关 键 词：肿瘤 整合素α_(v)β_(3) 体层摄影术 发射型计算机 单光子 

分 类 号：R73[医药卫生—肿瘤] R817[医药卫生—临床医学]