STAT家族在肿瘤中的作用及药物研发  

The Role of STAT Family in Tumor Progression and Drug Development

作　　者：钟文韬 张琦 李方琪 严婧 梁作文[3] 李晶[4] Zhong Wentao;Zhang Qi;Li Fangqi;Yan Jing;Liang Zuowen;Li Jing(The First Hospital of Jilin University,Changchun 130021;The Second Hospital of Jilin University,Changchun 130021;Department of Andrology,the First Hospital of Jilin University,Changchun 130021;Department of Pharmacology,College of Basic Medical Sciences,Jilin University,Changchun 130021)

机构地区：[1]吉林大学第一医院,长春130021 [2]吉林大学第二医院,长春130021 [3]吉林大学第一医院男科,长春130021 [4]吉林大学基础医学院药理学系,长春130021

出　　处：《国际老年医学杂志》2023年第3期347-350,共4页International Journal of Geriatrics

基　　金：吉林省科技发展计划项目(20210101320JC);吉林省发改委产业技术研究与开发项目(2020C034-2)。

摘　　要：信号转导及转录激活因子(STAT)家族参与免疫、炎症反应、细胞凋亡、肿瘤发生以及多种细胞生理过程。其中IL-6/JAK/STAT和IL-4/JAK/STAT信号通路在多种恶性肿瘤细胞中被激活,抑制STAT3异常激活成为抗肿瘤药物研发的重要靶标。本文对STAT家族的生物学功能及其与肿瘤的关系,以STAT家族分子为靶点的药物研发的进展作一综述。The signal transducer and activator of transcription(STAT)family is involved in immunity,inflammation,apoptosis,oncogenesis,and a variety of cellular physiological processes.The activation of IL-6/JAK/STAT and IL-4/JAK/STAT signaling pathways play an important role in a variety of malignant tumor cells and then the inhibition of abnormal activation of STAT3 has become a key target for the development of anti-tumor drugs.This article reviews the biological functions of the STAT family and their relationship with tumors,as well as the development of some drugs targeting STAT family molecules.

关 键 词：信号转导与转录激活因子 肿瘤 药物研发 

分 类 号：R730.2[医药卫生—肿瘤]