巨噬细胞极化在腹主动脉瘤形成中的研究进展  

Research progress of macrophage polarization in formation of abdominal aortic aneurysm

作　　者：吴亦昊 张昊[1] 涂思梅 殷宇涵 韩彦槊(指导) WU Yihao;ZHANG Hao;TU Simei;YIN Yuhan;HAN Yanshuo(School of Life and Pharmaceutical Sciences,Dalian University of Technology,Panjin 124221,China)

机构地区：[1]大连理工大学生命科学与药学学院,盘锦124221

出　　处：《中国免疫学杂志》2023年第5期1065-1072,共8页Chinese Journal of Immunology

基　　金：国家自然科学基金青年科学基金项目(81600370);辽宁省自然科学基金指导计划项目(2019-ZD-0789)。

摘　　要：慢性炎症反应是腹主动脉瘤(AAA)形成和破裂的核心环节。有研究证明,循环单核细胞源性巨噬细胞的极化状态可通过多种途径调控AAA的发生发展。浸润后的巨噬细胞受不同刺激极化为以M1型和M2型巨噬细胞为主的各类极化表型,既能通过释放细胞因子作用于其他免疫细胞调控炎症反应,也能通过细胞间通讯影响细胞外基质(ECM)的重塑过程。本文就巨噬细胞极化在AAA发生发展中的研究进展进行综述,旨在揭示巨噬细胞极化影响AAA的机制,以期通过作用于巨噬细胞极化的靶点治疗AAA。Chronic inflammatory response is the key link in formation and rupture of abdominal aortic aneurysm(AAA).Studies have proved that the polarization types of circulating monocyte-derived macrophages can regulate the occurrence and development of AAA through a variety of ways.Infiltrated macrophages are polarized by different stimuli into various types of polarization phenotypes,mainly M1 and M2 macrophages,which can not only regulate inflammatory response by releasing cytokines on other immune cells,but also through intercellular communication affects the remodeling process of extracellular matrix(ECM).This review summarizes the research progress of macrophage polarization in occurrence and development of AAA,aiming to reveal the mechanism of macrophage polarization affecting AAA,in order to treat AAA by acting on targets of macrophage polarization.

关 键 词：腹主动脉瘤 巨噬细胞 极化 细胞通讯 靶点 

分 类 号：R543.16[医药卫生—心血管疾病]