紫外线光功能化对二氧化钛纳米管表面改性钛种植体骨结合的影响  

The effect of UVA photofunetionalization on the osseointegration of titanium implants modified with titanium nanotubes

作　　者：盛美春[1] 罗小龙 谢广平 Sheng Meichun;Luo Xiaolong;Xie Guangping(Department of Stomatology,Huzhou first people’s Hospital,Huzhou 313000;Department of Stomatology,Ji’an hospital,Shanghai Oriental Hospital,Ji’an 340001;Department of Stomatology,Shanghai Pudong hospital,Shanghai 201399)

机构地区：[1]湖州市第一人民医院口腔科,湖州313000 [2]上海市东方医院吉安医院口腔科,吉安340001 [3]上海市浦东医院口腔科,上海201399

出　　处：《口腔材料器械杂志》2023年第2期116-119,共4页Chinese Journal of Dental Materials and Devices

基　　金：江西省自然科学基金项目(编号:20181BAB205038);湖州市科技计划项目(编号:2017GY48);复旦大学附属浦东医院重点专病诊治中心建设项目(编号:Tszb2023-11)

摘　　要：目的研究紫外线光功能化对二氧化纳米管钛表面改性钛种植体骨结合的影响。方法采用预阳极氧化法制备二氧化钛(TiO_(2))纳米管表面改性钛种植体,并用波长为250 nm、功率为2mW/cm^(2)紫外线(UVA)对种植体进行处理。将种植体植入SD大鼠股骨,12周后取含种植体骨组织制作组织切片,通过显微镜观察种植体周围骨组织形成情况并计算骨结合率。结果UVA处理组种植体周围新生骨组织多于未UVA处理组,且更致密。UVA处理组和未UVA处理组的骨结合率分别为(72.21±10.42)%和(44.98±9.62)%,两组之间的差异具有统计学意义(P<0.05)。结论UVA光功能化TiO_(2)纳米管表面改性有助于促进钛种植体骨结合。Objective The aim of this study was to study the effect of UVA photofunetionalization on the osseointegration of titanium implants modified with titanium nanotubes.Methods Titanium dioxide nanotube(TiO_(2))surface modified titanium implants were prepared by preanodization,and the implants were treated with UVA(wavelength:250nm,power:2 mW/cm^(2)).The implant was implanted into the femur of SD rats.After 12 weeks,the bone tissue containing the implant was taken to make tissue sections.The formation of bone tissue around the implant was observed by microscope and the bone binding rate was calculated.Results The new bone tissue around the implant in UVA treated group was more dense than that in the non UVA treated group.The osseo integration rate of the UVA treated group and the non UVA treated group were(72.21±10.42)%and(44.98±9.62)%,respectively.The difference between the two groups was statistically significant(P<0.05).Conclusion The surface modification of UVA photofunctionalized TiO_(2)nanotube was helpful to promote the osseointegration of titanium implant.

关 键 词：二氧化钛纳米管 光功能化 表面改性 骨结合 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R783.1[医药卫生—口腔医学]