复方苦参注射液联合TP方案化疗在肺癌、卵巢癌、宫颈癌治疗中网状Meta分析  

Network Meta-analysis of Compound Fufang Kushen Injection(复方苦参注射液)Combined with TP Chemotherapy in Lung Cancer,Ovarian Cancer and Cervical Cancer

作　　者：刘婷[1] 王文萍[2] LIU Ting;WANG Wenping(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2023年第4期144-152,共9页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1311600);辽宁省“兴辽英才计划”项目(XLYC1802008)。

摘　　要：目的系统评价复方苦参注射液联合TP方案(紫杉醇联合顺铂)化疗分别在肺癌、卵巢癌、宫颈癌治疗中的疗效及安全性。方法计算机检索中国知网(CNKI)、万方知识服务平台、维普网(VIP)、中国生物医学文献数据库(CBM)、Cochrane Library及PubMed等数据库,检索时限为建库至2021年12月。收集复方苦参注射液联合TP方案化疗在肺癌、卵巢癌、宫颈癌中随机对照研究。对纳入研究进行质量评价和数据提取,用软件ADDIS做网状Meta分析。结果最终纳入了34篇文献。网状Meta分析结果显示,3个癌种之间直接比较TP方案化疗联合复方苦参注射液组在改善近期疗效方面、减轻化疗所致恶心呕吐方面、减轻化疗所致肝功损害方面总体优于单纯化疗组。2个癌种(宫颈癌、肺癌)之间直接比较TP方案化疗联合复方苦参注射液组在减轻化疗所致白细胞减少方面、减轻化疗所致血红蛋白减少方面、减轻化疗所致血小板减少方面总体优于单纯化疗组。2个癌种(卵巢癌、肺癌)之间直接比较TP方案化疗联合复方苦参注射液组在减轻化疗所致肾功损害方面、减轻化疗所致神经毒性方面、减轻化疗所致脱发方面总体优于单纯化疗组。近期疗效改善概率:宫颈癌+卵巢癌>肺癌;减轻恶心呕吐概率:宫颈癌>肺癌>卵巢癌;肝功能损害减轻概率:肺癌>宫颈癌+卵巢癌;白细胞减少减轻概率:宫颈癌>肺癌;血红蛋白减少减轻概率:宫颈癌>肺癌;血小板减少减轻概率:肺癌>宫颈癌;肾功损害减轻概率:卵巢癌>肺癌;神经毒性减轻概率:卵巢癌>肺癌;脱发减轻概率:卵巢癌>肺癌。结论对于不同的癌种应用同样的化疗方案联合复方苦参注射液在改善近期疗效及减轻化疗毒性方面有差异。对于宫颈癌,复方苦参注射液在改善近期疗效,减轻化疗所致恶心呕吐、白细胞减少及血红蛋白减少方面有优势;对于卵巢癌,复方苦参注射液在�Objective To systematically evaluate the efficacy and safety of Compound Fufang Kushen Injection(复方苦参注射液)combined with TP(Paclitaxel combined with Cisplatin)chemotherapy in lung cancer,ovarian cancer and cervical cancer.Methods The computer searched CNKI,WanFang Knowledge Service Platform,VIP,China Biomedical Literature Database(CBM),Cochrane Library and PubMed databases,and the search time limit was until December 2021.A randomized controlled study of Compound Fufang Kushen Injection combined with TP regimen chemotherapy in lung cancer,ovarian cancer and cervical cancer.Quality evaluation and data extraction of the included studies were performed,and a network Meta-analysis was performed with the software ADDIS.Results A total of 34 articles were included.The results of the reticular Meta-analysis showed that the direct comparison between the three cancer groups was generally better than that of the chemotherapy alone group in terms of improving the short-term efficacy,alleviating nausea and vomiting caused by chemotherapy,and alleviating the liver damage caused by chemotherapy.The direct comparison between the two cancer species(cervical cancer and lung cancer)was generally better than that in the TP regimen chemotherapy combined with Compound Fufang Kushen Injection in reducing chemotherapy-induced leukopenia,reducing chemotherapy-induced hemoglobin reduction,and alleviating chemotherapy-induced thrombocytopenia.The direct comparison between the two cancer species(ovarian cancer and lung cancer)was generally better than that of the chemotherapy alone group in the TP regimen chemotherapy combined with Compound Fufang Kushen Injection in reducing the renal damage caused by chemotherapy,alleviating the neurotoxicity caused by chemotherapy,and alleviating the alopecia caused by chemotherapy.Improving the probability of near-term efficacy:cervical cancer+ovarian cancer>lung cancer;Reducing the probability of nausea and vomiting:cervical cancer>lung cancer>ovarian cancer;Reducing the probability of liv

关 键 词：复方苦参注射液 肺癌 宫颈癌 卵巢癌 TP方案化疗 网状Meta分析 

分 类 号：R734.2[医药卫生—肿瘤] R737.31[医药卫生—临床医学] R737.33