PVAT介导NO/NOS在脓毒血症患者血管舒缩活动中的作用研究进展  

Research progress on role of PVAT-mediated NO/NOS in vasomotor activity in patients with sepsis

作　　者：李堃 齐然 刘南斌 施宝民 LI Kun;QI Ran;LIU Nanbin(Department of General Surgery of Hepatobiliary and Pancreatic Surgery,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院普外肝胆胰外科,上海200065 [2]不详

出　　处：《外科研究与新技术》2023年第1期60-65,共6页Surgical Research and New Technique

摘　　要：脓毒血症是一种严重的致命性疾病,多种机制参与其发生及演进过程。血管周围脂肪组织(perivascular adipose tissue, PVAT)作为心血管疾病中的重要参与者,与血管关系密切,同时可分泌多种活性物质参与血管舒缩活动的改变。一氧化氮(nitric oxide, NO)及一氧化氮合酶(nitric oxide synthase, NOS)是重要的舒血管物质。本综述通过回顾既往文献资料,对PVAT介导NO/NOS在脓毒症中血管张力调节的机制做一探讨,以期有助于后续的研究实践及临床工作。Sepsis is a serious and fatal disease,and many mechanisms are involved in its occurrence and development.Perivascular adipose tissue(PVAT),as an important participant in cardiovascular disease,is closely related to blood vessels,and can secrete a variety of active substances to participate in the changes of vasomotor activity.Nitric oxide(NO)and nitric oxide synthase(NOS)are important vasodilators.By reviewing previous literature,we explored the mechanism of PVAT-mediated NO/NOS regulation in vascular tone in sepsis,in the hope of contributing to the follow-up research and clinical practice.

关 键 词：脓毒症 血管周围脂肪组织 一氧化氮 一氧化氮合酶 血管张力 

分 类 号：R365[医药卫生—病理学]