胞磷胆碱胶囊联合芪龙胶囊治疗老年急性脑梗死的疗效及对神经功能、血流动力学的影响  

Therapeutic effect of citicoline capsule combined with Qilong capsule on senile acute cerebral infarction and its influence on nervous function and hemodynamics.

作　　者：武蕊 杨春梅 姚彦 WU Rui;YANG Chun-mei;YAO Yan(Department of Pharmaceutical Sciences,2 Department of Neurology,3201 Hospital,Hanzhong Shaanxi 723000,China;Department of Laboratory Pathology,986 Air Force Hospital,Xi'an Shaanxi 710054,China)

机构地区：[1]三二〇一医院药学部,陕西汉中723000 [2]三二〇一医院神经内科,陕西汉中723000 [3]空军第九八六医院检验病理科,陕西西安710054

出　　处：《临床和实验医学杂志》2023年第8期805-809,共5页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金(编号:21672046)。

摘　　要：目的探讨胞磷胆碱胶囊联合芪龙胶囊治疗老年急性脑梗死的疗效及对神经功能、血流动力学的影响。方法前瞻性选取2019年1月至2022年12月三二〇一医院收治的80例急性脑梗死患者,按照随机数字表法分为观察组与对照组,每组40例。对照组在溶栓后采取常规西医治疗,观察组以对照组为基础,增加胞磷胆碱胶囊联合芪龙胶囊治疗。比较两组的临床疗效、神经功能[神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)、神经生长因子(NGF)]、血流动力学指标(红细胞比容、血浆黏度、全血黏度)、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1、IL-6]水平以及不良反应发生情况。结果观察组治疗总有效率为95.00%,明显高于对照组(75.00%),差异有统计学意义(P<0.05)。治疗后,两组患者NSE、NGF水平较治疗前均降低,BDNF水平较治疗前升高,且观察组NSE、NGF水平分别为(29.21±8.93)U/L、(10.68±2.12)pg/mL,均低于对照组[(41.12±6.12)U/L、(15.63±3.52)pg/mL],BDNF水平为(6.32±2.02)ng/mL,高于对照组[(4.02±1.25)ng/mL],差异均有统计学意义(P<0.05)。治疗后,两组患者红细胞比容、血浆黏度、全血黏度均降低,且观察组分别为(35.12±3.12)%、(1.32±0.12)mPa·s、(3.63±0.52)mPa·s,低于对照组[(40.21±3.93)%、(2.02±0.25)mPa·s、(4.68±1.12)mPa·s],差异均有统计学意义(P<0.05)。治疗后,两组患者TNF-α、IL-1、IL-6水平均较治疗前降低,且观察组分别为(45.12±8.14)pg/mL、(14.12±3.16)μg/L、(87.13±9.57)pg/mL,均低于对照组[(45.12±8.14)pg/mL、(14.12±3.16)μg/L、(185.68±23.15)pg/mL],差异均有统计学意义(P<0.05)。两组患者均无严重不良反应发生,且肾功能轻度异常、呕吐、腹泻、肝功能轻度异常等不良反应发生率比较,差异无统计学意义(P>0.05)。结论老年急性脑梗死患者在常规西医治疗基础上采取胞磷胆碱胶囊联合芪龙胶囊治疗能够进一步提升疗效,改善�Objective To investigate the therapeutic effect of citicoline capsule combined with Qilong capsule on elderly patients with acute cerebral infarction and its influence on nervous function and hemodynamics.Methods A total of 80 patients with acute cerebral infarction admitted to 3201 Hospital from January 2019 to December 2022 were prospectively selected and divided into observation group and control group according to the random number table,with 40 patients in each group.The control group took conventional western medicine treatment after thrombolysis.Based on the control group,the observation group was added to citicoline capsule combined with Qilong capsule treatment.Clinical efficacy,neurological function[neuron specific enolase(NSE),brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)],hemodynamic indexes(hematocrit,plasma viscosity,whole blood viscosity),inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin(IL)-1,IL-6,]levels and adverse reactions were compared.Results The total effective rate of the observation group was 95.00%,which was higher than that of the matched group(75.00%),the difference was statistically significant(P<0.05).After treatment,the levels of NSE and NGF in the two groups were lower than those before treatment,and the levels of BDNF were higher than those before treatment,the levels of NSE and NGF in the observation group were(29.21±8.93)U/L,(10.68±2.12)pg/mL,respectively,which were lower than those in the control group[(41.12±6.12)U/L,(15.63±3.52)pg/mL],and the levels of BDNF were(6.32±2.02)ng/mL,which were higher than those in the control group[(4.02±1.25)ng/mL],and the differences were statistically significant(P<0.05).After treatment,the hematocrit,plasma viscosity and whole blood viscosity of the two groups were decreased,and those in the observation group were(35.12±3.12)%,(1.32±0.12)mPa·s,(3.63±0.52)mPa·s,respectively,which were lower than those in the control group[(40.21±3.93)%,(2.02±0.25)mPa·s,(4.68±1.12)mPa·s],and the differenced were

关 键 词：胞磷胆碱胶囊 芪龙胶囊 急性脑梗死 神经功能 血流动力学 临床疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]