穴位刺激疗法治疗肝癌患者呃逆疗效的Meta分析  

Meta-Analysis of the Therapeutic Effect of Acupoint Stimulation Therapy on Hiccups in Patients with Liver Cancer

作　　者：邵国梁[1] 黄绍磊 韩晶[2] 王萌萌 杨佃会[1,2] Shao Guoliang;Huang Shaolei;Han Jing;Wang Mengmeng;Yang Dianhui(School of Acupuncture and Tuina,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Afiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]山东中医药大学针灸推拿学院,济南250014 [2]山东中医药大学附属医院,济南250011

出　　处：《世界科学技术-中医药现代化》2023年第1期413-421,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：山东省自然科学基金委员会青年项目(ZR2020QH315):耳穴综合疗法治疗月经性偏头痛疗效差异的蛋白组学研究,负责人:王萌萌。

摘　　要：目的通过Meta分析系统评价穴位刺激疗法治疗肝癌患者呃逆的治疗效果。方法检索中国知网(CNKI)、中国生物医学文献数据库(SinoMed)、维普中文科技期刊全文数据库(VIP)、万方数据库(CSPD)等中文数据库,PubMed、EMBASE、Clinical Trials、the Cochrane Library等外文数据库,收集关于穴位刺激疗法治疗肝癌患者呃逆的临床随机对照试验研究的文献,检索年限从建库至2022年3月。提取文献的相关原始数据,通过Meta分析穴位刺激疗法和单纯西药治疗肝癌患者呃逆的总有效率、治愈率、显效率、呃逆症状评分、生效时间和不良反应发生率,用漏斗图评估发表偏倚。结果本研究纳入10篇文献,涉及627名患者。Meta分析结果显示:(1)穴位刺激疗法治疗肝癌呃逆在总有效率方面较西药治疗具有优势(RR=1.42,95%CI(1.22,1.65),P<0.05),差异具有统计学意义;(2)穴位刺激疗法治疗肝癌呃逆在治愈率方面较西药治疗具有优势(RR=2.88,95%CI(2.06,4.02),P<0.05),差异具有统计学意义;(3)穴位刺激疗法治疗肝癌呃逆在显效率方面无统计学意义(P>0.05);(4)穴位刺激疗法治疗肝癌呃逆在不良反应发生率方面较西药治疗具有优势(RR=0.15,95%CI(0.04,0.54),P<0.05),差异具有统计学意义;(5)穴位刺激疗法治疗肝癌呃逆在呃逆症状评分方面较西药治疗具有优势(SMD=-2.14,95%CI(-2.63,-1.66),P<0.05),差异具有统计学意义;(6)穴位刺激疗法治疗肝癌呃逆在生效时间方面较西药治疗具有优势(SMD=-2.88,95%CI(-4.91,-0.84),P<0.05),差异具有统计学意义。结论穴位刺激疗法在治疗肝癌患者呃逆的疗效和生效时间上均优于单纯西药治疗;穴位刺激疗法不良反应发生率较少,已有报道中仅有2例出现疲劳感,安全性较高。临床上可使用穴位刺激疗法治疗肝癌患者呃逆,发挥中医特色疗法治疗该病种的优势。但纳入文献证据等级偏低,存在发表偏倚,临床医师需按实际情况进�Objective To systematically evaluate the therapeutic effect of acupoint stimulation therapy on hiccups in patients with liver cancer through Meta-analysis.Methods Search Chinese databases such as CNKI,China Biomedical Literature Database(SinoMed),VIP Chinese Science and Technology Periodicals Full-text Database(VIP),Wanfang Database(CSPD),and foreign databases such as PubMed,EMBASE,Clinical Trials,the Cochrane Library,etc.,to collect literatures on clinical randomized controlled experimental studies of acupoint stimulation therapy for the treatment of hiccups in patients with liver cancer.The retrieval period is from the establishment of the database to March 2022.The relevant raw data of the literature were extracted,and the total effective rate,cure rate,markedly effective rate,hiccups symptom score,effective time and incidence of adverse reactions of acupoint stimulation therapy and pure western medicine in the treatment of hiccups in patients with liver cancer were analyzed by meta-analysis,and the publication bias was evaluated by funnel plot.Results This study included 10 articles involving 627 patients.The results of Meta-analysis showed:(1)Acupoint stimulation therapy was superior to western medicine treatment in the total effective rate of acupoint stimulation therapy(RR=1.42,95% CI(1.22,1.65),P0.05);(2)Acupoint stimulation therapy for liver cancer hiccups has an advantage over Western medicine in terms of cure rate(RR=2.88,95% CI(2.06,4.02),P0.05),the difference was statistically significant;(3) There was no significant difference in the markedly effective rate of acupoint stimulation therapy in the treatment of liver cancer hiccups(P 0.05);(4)Acupoint stimulation therapy for liver cancer hiccups was superior to western medicine in the incidence of adverse reactions(RR=0.15,95% CI(0.04,0.54),P0.05),and the difference was statistically significant;(5) Acupoint stimulation therapy Liver cancer hiccup had an advantage over western medicine treatment in the score of hiccup symptoms(SMD=-2.14,95% CI(-2.63,-1

关 键 词：穴位刺激疗法 肝癌 呃逆 META分析 

分 类 号：R-058[医药卫生]