Manipulating the antioxidative capacity of melanin-like nanoparticles by involving condensation polymerization  

作　　者：Peng Yang Tianyou Wang Jianhua Zhang Hengjie Zhang Wanjie Bai Gaigai Duan Wei Zhang Jinrong Wu Zhipeng Gu Yiwen Li 

机构地区：[1]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China [2]Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,International Innovation Center for Forest Chemicals and Materials,College of Materials Science and Engineering,Nanjing Forestry University,Nanjing 210037,China [3]Laboratory for Biomaterials and Drug Delivery,Department of Anesthesiology,Critical Care and Pain Medicine,Boston Children’s Hospital,Harvard Medical School,Boston,Massachusetts 02115,USA

出　　处：《Science China Chemistry》2023年第5期1520-1528,共9页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(52225311);the Fundamental Research Funds for Central Universities。

摘　　要：Melanin is ubiquitous in nature and plays important roles in physiological activities especially in keeping the oxidative balance.Both natural and synthetic melanin were synthesized via the free radical polymerization of 5,6-dihydroxyindole(DHI)monomer,which may lead to the inherent compactπ-conjugation stacking microstructures and finally results in limited antioxidative capacities.To address this issue,we have strived to involve condensation polymerization during the melanin synthetic process,aiming to disrupt the compact stacking microstructures and improve the total antioxidative performance.The resulting melaninlike nanoparticles(NPs)indeed possessed less compact stackingπ-conjugation structures and decreased density,which further demonstrated enhanced antioxidative abilities compared with conventional melanin-like polymers such as poly-5,6-dihydroxyindole(Poly-DHI)and polydopamine(PDA).Their excellent free radical scavenging capability was further confirmed by the intracellular cell protection effects against reactive oxygen species(ROS)as well as in vivo therapy for acute diseases including acute kidney injury and acute liver injury.This work would promote future work toward new types of melanin-inspired nanomaterials with tunable and improved functions beyond nature.

关 键 词：MELANIN condensation polymerization free radical polymerization POLYDOPAMINE antioxidative-therapy 

分 类 号：TB383.1[一般工业技术—材料科学与工程]