双靶点软通道微创穿刺引流术对高血压丘脑出血患者血肿清除效果、颅内压及血管内皮功能的影响  

Influences of double target soft channel minimally invasive puncture drainage on hematoma clearance effect,intracranial pressure and vascular endothelial function in patients with hypertensive thalamic hemorrhage

作　　者：屈新刚 段飞 QU Xingang;DUAN Fei(the People's Hospital of Qian County,Xianyang 713300;the First People's Hospital of Xianyang,Xianyang 712000,China)

机构地区：[1]乾县人民医院,陕西咸阳713300 [2]咸阳市第一人民医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2023年第15期57-60,共4页Clinical Research and Practice

摘　　要：目的探讨双靶点软通道微创穿刺引流术在高血压丘脑出血患者中的应用效果。方法选取2019年1月至2021年1月我院收治的90例高血压丘脑出血患者作为研究对象,以抽签法将其随机分为对照组和观察组,各45例。对照组采用侧脑室穿刺联合体外引流术,观察组采用双靶点软通道微创穿刺引流术。比较两组的治疗效果。结果观察组术后5 d内血肿清除率、脑积水缓解率高于对照组(P<0.05)。观察组术后即刻、术后1 d的颅内压低于对照组,血肿完全消散时间、住院时间短于对照组(P<0.05)。术后1 d,观察组的内皮素-1(ET-1)水平低于对照组,一氧化氮(NO)水平高于对照组(P<0.05)。术后1 d,观察组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。术后1 d,观察组的神经元特异性烯醇化酶(NSE)、S100-β水平低于对照组(P<0.05)。结论双靶点软通道微创穿刺引流术有助于提高高血压丘脑出血患者的血肿清除率、脑积水缓解率,降低颅内压,改善血管内皮功能,减轻炎症反应,值得临床推广和应用。Objective To explore the application effect of double target soft channel minimally invasive puncture drainage in patients with hypertensive thalamic hemorrhage.Methods A total of 90 patients with hypertensive thalamic hemorrhage admitted in our hospital from January 2019 to January 2021 were selected as the study objects.The patients were randomly divided into control group and observation group by drawing lots,with 45 cases in each group.The control group was treated with lateral ventricle puncture combined with external drainage,and the observation group was treated with double target soft channel minimally invasive puncture drainage.The treatment effects of the two groups were compared.Results The hematoma clearance rate and hydrocephalus remission rate in the observation group were higher than those in the control group within 5 d after operation(P<0.05).The intracranial pressure of the observation group immediately after operation and 1 d after operation was lower than that of the control group,and the complete disappearance time of hematoma and hospitalization time were shorter than those of the control group(P<0.05).One day after operation,the level of endothelin-1(ET-1)in the observation group was lower than that in the control group,and the level of nitric oxide(NO)was higher than that in the control group(P<0.05).One day after operation,the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).One day after operation,the levels of neuron-specific enolase(NSE)and S100-βin the observation group were lower than those in the control group(P<0.05).Conclusion Double target soft channel minimally invasive puncture drainage can improve the hematoma clearance rate,hydrocephalus remission rate,reduce intracranial pressure,improve vascular endothelial function,and alleviate inflammatory response in patients with hypertensive thalamic hemorrhage.It is worthy of clinical promotion and application.

关 键 词：双靶点软通道微创穿刺引流术 高血压丘脑出血 血肿清除效果 颅内压 血管内皮功能 

分 类 号：R743.34[医药卫生—神经病学与精神病学]