超声C-TIRADS联合BRAF^(V600E)检测对AUS/FLUS甲状腺结节良恶性的诊断价值  

Diagnostic Value of Ultrasound C-TIRADS Combined with BRAF^(V600E) Detection in Benign and Malignant Thyroid Nodules of AUS/FLUS

作　　者：王琰娟[1] 焦华杰 韩涛 王福霞[1] 马丽园[1] 彭晖晖 Wang Yanjuan;Jiao Huajie;Han Tao;Wang Fuxia;Ma Liyuan;Peng Huihui(Department of Ultrasound,General Hospital of Ningxia Medical University,Yinchuan 750001,China;Medical Imaging Department,Ningxia People1s Hospital,Yinchuan 750001,China)

机构地区：[1]宁夏医科大学总医院超声科,银川市750001 [2]宁夏人民医院医学影像科,银川市750001

出　　处：《中国超声医学杂志》2023年第4期369-372,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的探讨中国版甲状腺影像报告和数据系统(C-TIRADS)联合BRAF^(V600E)检测对非典型结节/无明确意义滤泡样损伤(AUS/FLUS)甲状腺结节良恶性的诊断效能。方法选取100例AUS/FLUS甲状腺结节患者,患者接受甲状腺超声检查和BRAF^(V600E)基因突变检测,分析C-TIRADS、BRAF^(V600E)基因诊断单用及联合使用对甲状腺结节良恶性的鉴别诊断效能。结果C-TIRADS分类诊断出恶性结节71例、良性29例。BRAF^(V600E)基因突变检测显示阳性63例,阴性37例。C-TIRADS联合BRAF^(V600E)基因突变诊断阳性82例,阴性18例。与C-TIRADS、BRAF^(V600E)单用相比,两项联合对甲状腺结节的诊断灵敏度(98.78%)、准确度(96.00%)及阴性预测值(88.89%)更高(P<0.05);与C-TIRADS相比,两项联合对甲状腺恶性结节的特异度(88.89%)更高(P<0.05)。结论C-TIRADS分类方法对甲状腺结节良恶性判定有较高的诊断效能,联合BRAF^(V600E)基因突变检测可进一步提高恶性甲状腺结节的诊断灵敏度及准确度。Objective To explore the diagnostic efficacy of the Chinese version of thyroid imaging reporting and data system(C-TIRADS)combined with BRAF^(V600E) detection in the diagnosis of benign and malignant thyroid nodules with atypical nodules/unspecified follicular lesions(AUS/FLUS).Methods We selected 1oo patients with AUS/FLUS thyroid nodules,who received thyroid ultrasound examination and BRAF^(V600E) gene mutation detection,and analyzed the differential diagnosis efficacy of C-TIRADS and BRAF^(V600E) gene diagnosis alone and in combination for benign and malignant thyroid nodules.Results C-TIRADS clssified 71 malgnant nodules and 29 benign nodules.BRAF^(V600E) gene mutation detection showed that 63 cases were positive and 37 cases were negative C-TIRADS combined with BRAF^(V600E) gene mutation diagnosis was positive in 82 cases and negative in 18 cases.Compared with C-TIRADS and BRAF^(V600E) alone,the sensitivity(98.78%),acuracy(96.00%)and negative predictive value(88.89%)of the combination of the two methods for thyroid nodules were higher(P<0.05).Compared with C-TIRADS,the specificity(88.89%)of the combination of the two methods for thyroid malignant nodules was higher(P<O.05).Conclusions C-TIRADS classification method has high diagnostic efficiency in the determination of benign and malignant thyroid nodules.combined with BRAF^(V600E) gene mutation detection can further improve the diagnostic sensitivity and accuracy of malignant thyroid nodules.

关 键 词：甲状腺结节 基因突变 超声 甲状腺影像报告和数据系统 诊断 

分 类 号：R445.1[医药卫生—影像医学与核医学] R581[医药卫生—诊断学] R736.1[医药卫生—临床医学]