皂苷类化合物抗肝癌作用机制的研究进展  

Research progress on the mechanism of saponins against hepatocellular carcinoma

作　　者：张哲 龙佳瑶 陈晓勇 饶利兵 林玲 唐根云 ZHANG Zhe;LONG Jia-yao;CHEN Xiao-yong;RAO Li-bing;LIN Ling;TANG Gen-yun(Graduate School of Guangzhou Medical University,Guangzhou 510000;Hunan University of Medicine,Huaihua Hunan 418000;Sanya Central Hospital,Sanya Hainan 572000)

机构地区：[1]广州医科大学研究生院,广州510000 [2]湖南医药学院,湖南怀化418000 [3]三亚中心医院,海南三亚572000

出　　处：《中南药学》2023年第5期1307-1314,共8页Central South Pharmacy

基　　金：国家自然科学基金项目(No.81703821)。

摘　　要：皂苷类化合物是一类苷元为三萜或甾烷类的糖苷类化合物,具有广泛的抗肿瘤作用,其具体机制包括抑制肝癌细胞增殖、促进细胞凋亡、促进细胞自噬、阻滞细胞周期、抑制肿瘤侵袭转移及肿瘤耐药性。本文通过检索近年来国内外最新研究成果,首次系统阐述滇重楼、人参、柴胡、桔梗、地肤子传统植物药中主要天然皂苷类化合物的抗肝癌作用机制,以期为肝癌的治疗与药物的研发提供参考。Saponins are a class of glycosides with triterpenoids or steranes,which have a wide range of anti-tumor effects.These saponins have been found several mechanisms of anti-hepatocellular carcinoma,such as inhibiting the proliferation of hepatocellular carcinoma cells,promoting apoptosis,facilitating autophagy,arresting cell cycle,repressing tumor invasion and metastasis and tumor drug resistance.Therefore,this paper reviewed the mechanism of anti-hepatocellular carcinoma of natural saponins in the traditional phytomedicine,including Paris polyphylla var.yunnanensis(Franch.)Hand.-Mazz,Panax ginseng,Radix Bupleuri,Platycodon grandiflorum,and Kochiae Fructus,by retrieving the latest research at domestic and overseas in recent years for the first time,in order to provide novel reference for the treatment and drug development of hepatocellular carcinoma.

关 键 词：皂苷类化合物 肝癌 作用机制 研究进展 

分 类 号：R730[医药卫生—肿瘤] R285[医药卫生—临床医学]