Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota  

作　　者：Libin Pan Hang Yu Jie Fu Jiachun Hu Hui Xu Zhengwei Zhang Mengmeng Bu Xinyu Yang Haojian Zhang Jinyue Lu Jiandong Jiang Yan Wang 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100050,China Received 5 September 2022,Revised 8 November

出　　处：《Acta Pharmaceutica Sinica B》2023年第4期1537-1553,共17页药学学报（英文版）

基　　金：supported by the National Key R&D Program of China(No.2022YFA0806400);the CAMS Innovation Fund for Medical Sciences(CIFMS;Nos.2022-I2M-JB-011,2022-I2M-2-002,and 2021-I2M-1-007,China);National Natural Science Foundation of China(Nos.82173888 and 81973290);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study(Z141102004414062,China)。

摘　　要：At present,clinical interventions for chronic kidney disease are very limited,and most patients rely on dialysis to sustain their lives for a long time.However,studies on the gut—kidney axis have shown that the gut microbiota is a potentially effective target for correcting or controlling chronic kidney disease.This study showed that berberine,a natural drug with low oral availability,significantly ameliorated chronic kidney disease by altering the composition of the gut microbiota and inhibiting the production of gut-derived uremic toxins,including p-cresol.Furthermore,berberine reduced the content of pcresol sulfate in plasma mainly by lowering the abundance of g_Clostridium_sensu_stricto_1 and inhibiting the tyrosine—p-cresol pathway of the intestinal flora.Meanwhile,berberine increased the butyric acid producing bacteria and the butyric acid content in feces,while decreased the renal toxic trimethylamine N-oxide.These findings suggest that berberine may be a therapeutic drug with significant potential to ameliorate chronic kidney disease through the gut—kidney axis.

关 键 词：Chronic kidney disease Gut microbiota BERBERINE Gut—kidney axis CLOSTRIDIUM P-CRESOL Uremic toxins p-Cresol sulfate 

分 类 号：R285[医药卫生—中药学]