表没食子儿茶素没食子酸酯抗肿瘤作用机制的研究进展  

Research progress on anticancer mechanism of (-)-epigallocatechin gallate

作　　者：董雅楠 DONG Ya-nan(Department of Pharmacy,The People's Hospital of Jizhou District,Tianjin,Tianjin 301900,China)

机构地区：[1]天津市蓟州区人民医院药剂科,天津301900

出　　处：《现代药物与临床》2023年第4期1008-1013,共6页Drugs & Clinic

基　　金：省部共建食品营养与安全国家重点实验室开放课题(20210829)。

摘　　要：绿茶中的活性成分已经被证明具有预防和控制癌症的作用,其中表没食子儿茶素没食子酸酯(EGCG)抗癌活性最高。EGCG能够通过调控氧化应激、阻滞肿瘤细胞周期、抑制肿瘤血管形成、诱导肿瘤细胞凋亡等途径实现抗肿瘤效果。因此对EGCG抗肿瘤作用机制的进行了综述,以期为EGCG的临床应用提供参考。The active ingredients in green tea have been proved to have anticancer effects,and(−)-epigallocatechin gallate(EGCG)had the highest anticancer activity.EGCG could achieve anticancer effects by regulating oxidative stress,blocking tumor cell cycle,inhibiting tumor angiogenesis,and inducing cancer cell apoptosis.This article reviews the mechanism of anticancer action of EGCG in order to provide reference for its clinical application.

关 键 词：表没食子儿茶素没食子酸酯 氧化应激 细胞周期 肿瘤血管形成 细胞凋亡 

分 类 号：R979.1[医药卫生—药品]