三丙烯微球联合碘油经脾动脉部分栓塞术对乙肝肝硬化肝功能和生存期的影响  

Effect of partial splenic artery embolization using triple propylene microspheres combined with lipiodol on the hepatic functions and survival time in patients with hepatitis B cirrhosis

作　　者：吴卫东 蔡恒毅 WU Weidong;CAI Hengyi(Department of Vascular Surgery,Jiujiang Municipal Third People's Hospital,Jiujiang,Jiangxi Province 332000,China)

机构地区：[1]九江市第三人民医院血管外科,江西九江332000 [2]九江市第三人民医院重肝科

出　　处：《介入放射学杂志》2023年第4期381-384,共4页Journal of Interventional Radiology

基　　金：江西省卫生计生委科技计划(SKJP220201166)。

摘　　要：目的 探讨三丙烯微球联合碘油经脾动脉部分栓塞术对乙肝肝硬化患者肝功能和生存期的影响。方法 按前瞻性随机对照研究原则将120例乙肝肝硬化脾功能亢进患者分为三丙烯微球联合碘油经脾动脉部分栓塞组(1组)和空白对照组(2组),选取同期接受明胶海绵颗粒经脾动脉栓塞患者60例(3组),手术切除脾脏患者48例(4组)。比较患者入组时、治疗24个月时Child-Pugh评分、分级、血红蛋白浓度、白细胞和血小板计数、腹水发生次数及24个月生存期的差异。结果 1组疗效优于2、3、4组,差异有统计学意义(P<0.05);2、3、4组疗效比较差异无统计学意义(P>0.05);1组24个月生存期优于2、3、4组,差异有统计学意义(P<0.05);2、3、4组比较差异无统计学意义(P>0.05)。结论 三丙烯微球联合碘油经脾动脉部分栓塞治疗可改善乙肝肝硬化患者肝功能,延长患者24个月生存期。Objective To evaluate the effect of partial splenic artery embolization by using triple propylene microspheres plus lipiodol on the hepatic functions and survival time in patients with hepatitis B cirrhosis. Methods According to the principle of a prospective randomized controlled study, 120 patients with hepatitis B cirrhotic hypersplenism were divided into partial splenic artery embolization by using triple propylene microspheres plus lipiodol group(study group) and blank control group(control group). During the same period, other 60 patients who received splenic artery embolization using gelatin sponge granules were collected as gelatin sponge group, and 48 patients who received surgical splenectomy were collected as surgery group. The Child-Pugh score, grade, hemoglobin concentration, leukocytes, platelets, and the number of ascites occurrence were determined at the time when the patient was enrolled in the study as well as at 24 months after treatment. The 24-month survival rate of each group was calculated. The results of the above indexes were compared between each other among the four groups. Results The curative effect of the study group was better than that of the control group, gelatin sponge group and surgery group, the differences were statistically significant(P<0.05), while the differences the in curative effect between each other among the control group, gelatin sponge group and surgery group were not statistically significant(P>0.05). The 24-month survival rate of the study group was better than that of the control group, gelatin sponge group and surgery group, the differences were statistically significant(P<0.05), while the differences in the 24-month survival rate between each other among the control group, gelatin sponge group and surgery group were not statistically significant(P>0.05). Conclusion For the treatment of hepatitis B cirrhotic hypersplenism, partial splenic artery embolization by using triple propylene microspheres plus lipiodol can improve the patient's hepatic functions and 24

关 键 词：联合栓塞 肝功能 生存期 

分 类 号：R575.2[医药卫生—消化系统]