基于4DCT的肺功能成像在肺部肿瘤放射治疗中的应用进展  

Application of 4DCT-based lung functional imaging in radiotherapy for lung cancer

作　　者：钟文静 李英[1] 崔海霞 Zhong Wenjing;Li Ying;Cui Haixia(Department of Oncology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院肿瘤科,重庆400016

出　　处：《中华放射肿瘤学杂志》2023年第5期481-487,共7页Chinese Journal of Radiation Oncology

摘　　要：放射性肺炎是目前肺癌放疗中不可忽视的不良反应。有研究推荐将功能成像技术引入肺癌放疗计划中,其中4DCT因其操作简便、空间分辨率高、不需要额外费用等优点,相比于单光子发射计算机断层扫描(SPECT)-CT、正电子发射计算机断层扫描(PET)-CT、MRI在肺癌的放疗中有更好的应用前景。利用4DCT获取患者的肺功能状态,一方面可以预测放射性肺不良反应,有助于临床医生及早干预,另一方面有助于进行功能肺回避的放疗,减少正常肺组织的损伤,减轻胸部不良反应,可能在未来具有更广泛的应用价值。本文就近年来基于4DCT的功能肺成像算法及肺癌放射治疗应用的研究进展做一综述。Radiation pneumonia is a side effect that cannot be ignored in the current radiation therapy for lung cancer.At present,there are studies and reports of the introduction of functional imaging technology into lung cancer radiotherapy plans,in which 4DCT has better application prospects in radiotherapy for lung cancer because of its advantages of simple operation,high spatial resolution and no additional cost,etc.Compared with single-photon emission computed tomography(SPECT)-CT,positron emission tomography(PET)-CT,MRI has a better application prospect in radiotherapy of lung cancer.The use of 4DCT to obtain the patient's lung function status can predict radiation pulmonary toxicity and assist clinicians to deliver prompt interventions.Moreover,it can help carry out radiotherapy for functional lung avoidance,mitigate the damage of normal lung tissues,and alleviate chest toxicity,which may have wider application value in the future.In this article,research progress on functional lung imaging algorithms based on 4DCT and the application of radiation therapy for lung cancer was reviewed.

关 键 词：肺肿瘤/放射疗法 放射性肺炎 四维CT 功能肺 通气成像 

分 类 号：R734.2[医药卫生—肿瘤]