移植后中枢神经系统淋巴组织增殖性疾病1例  

Central nervous system post-transplant lymphoproliferative disorder:a case report

作　　者：崔博 王丹丹[2] 朴月善[2] 李存江[1] 樊春秋[1] Cui Bo;Wang Dandan;Piao Yueshan;Li Cunjiang;Fan Chunqiu(Department of Neurology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;Department of Pathology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053 [2]首都医科大学宣武医院病理科,北京100053

出　　处：《中华神经科杂志》2023年第5期549-552,共4页Chinese Journal of Neurology

摘　　要：移植后淋巴组织增殖性疾病(PTLD)是与实体器官或造血干细胞移植相关的一组综合征,中枢神经系统PTLD(CNS-PTLD)非常罕见。文中报道1例肾移植术后24年的CNS-PTLD患者,病理学证实为弥漫大B细胞淋巴瘤,脑脊液病原学二代测序及病理学检查结果均支持Epstein-Barr病毒感染可能与之发生相关。Post-transplant lymphoproliferative disorder(PTLD)is a solid organ or hematopoietic stem cells transplant associated syndrome,and central nervous system PTLD(CNS-PTLD)is extremely rare.A case of CNS-PTLD occurring after 24 years of kidney transplant was reported,and pathological examination proved it to be diffuse large B cell lymphoma.Cerebrospinal fluid next generation sequencing and pathological examination supported that Epstein-Barr virus infection was associated with it.

关 键 词：移植后淋巴组织增殖性疾病 中枢神经系统 弥漫大B细胞淋巴瘤 EPSTEIN-BARR病毒 

分 类 号：R741[医药卫生—神经病学与精神病学]