间充质干细胞及其修饰体在肝纤维化治疗中的作用研究进展  

Research progress of mesenchymal stem cells and their modifiers in treatment of liver fibrosis

作　　者：丁健 宋亮 阮柏 王琳 Ding Jian;Song Liang;Ruan Bai;Wang Lin(Medical Experimental Center,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 721000,China;Department of Hepatobiliary Surgery,Xijing Hospital,Air Force Military Medical University,Xi’an,Shaanxi 710000,China)

机构地区：[1]陕西中医药大学医学科研实验中心,陕西咸阳712000 [2]空军军医大学西京医院肝胆外科,陕西西安710000

出　　处：《解放军医学杂志》2023年第5期609-614,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81800533)。

摘　　要：肝纤维化是由饮酒、病毒性肝炎、自身免疫性肝炎、非酒精性脂肪性肝炎(NASH)、非酒精性脂肪性肝病(NAFLD)及胆汁淤积肝脏疾病等多种因素引起的慢性肝损伤,上述因素对肝脏的共同影响是产生慢性炎症,导致异常的肝脏炎症、坏死、再生、修复过程。间充质干细胞(MSCs)是一种多能干细胞,能够植入靶组织并分泌多种因子,从而改变或改善受损组织的功能。干细胞具有自我更新、多潜能分化及低免疫原性等优点,因此MSCs的分化潜力及旁分泌特性使其成为组织修复的重要选择。本文主要就MSCs及其修饰体在肝纤维化治疗中的作用及研究进展进行综述。Liver fibrosis is a response to chronic liver injury caused by a variety of factors,such as alcohol consumption,viral hepatitis,autoimmune hepatitis,non-alcoholic steatohepatitis(NASH),non-alcoholic fatty liver disease(NAFLD)and cholestatic liver disease.The combined effect of all these factors on the liver is to produce chronic inflammation leading to an abnormal wound-healing response.Mesenchymal stem cells(MSCs)are pluripotent stem cells that are able to implant into target tissues and secrete a variety of factors that can alter or improve the function of damaged tissues.Stem cells have the advantages of self-renewal,pluripotent differentiation and low immunogenicity.Due to their differentiation potential and paracrine characteristics,MSCs are the key for repair.This review focuses on the mechanism and progress of MSCs and their modifiers in liver fibrosis.

关 键 词：肝纤维化 肝损伤 间充质干细胞 

分 类 号：R575[医药卫生—消化系统]