质谱相关四极场的设计思路探讨  

Discussion on Design Ideas of Quadrupole Field of Mass Spectrometry

作　　者：贾滨 杨茂璘 刘吉星 赵高升[1] 黄玉梁 程平[1] JIA Bin;YANG Mao-lin;LIU Ji-xing;ZHAO Gao-sheng;HUANG Yu-liang;CHENG Ping(School of Environmental and Chemical Engineering,Shanghai University,Shanghai 200444,China)

机构地区：[1]上海大学环境与化学工程学院,上海200444

出　　处：《质谱学报》2023年第3期348-356,I0002,共10页Journal of Chinese Mass Spectrometry Society

基　　金：上海市科技创新行动计划项目(21SQBS01900)。

摘　　要：四极杆和离子阱等基于四极场理论的质谱技术自诞生至今已发展得较为成熟,并对质谱学产生了重大影响。本文通过对四极场的设计和产生过程进行完整的物理和数学公式推演与诠释,着重讨论了四极场电势分布的获得过程,电极形状、电极上电压等边界条件的获得过程,以及根据四极场电势分布推演出的四极杆结构和离子阱结构的过程等。该内容是对四极场质谱理论相关阐述的重要补充,有助于更加深入地理解四极场的基本原理。同时,还提供了一种潜在的质量分析器设计思路,对质谱相关的理论研究和原始创新的研发工作具有重要的借鉴意义。The mass analyzer based on quadrupole field theory,including quadrupole and ion trap,control and screen ions by a non-magnetic,alternating electric field,which was the first proposed by Professor Paul in 1953.Since the birth of quadrupole,ion trap and other related mass spectrometry technologies have been developed relatively maturely,which have made a significant impact and contribution to mass spectrometry.This paper deduced and interpretd the complete physical and mathematical formulae of the design and generation process of the quadrupole field.The process of obtaining the potential distribution of the quadrupole field,the obtaining process of boundary conditions such as electrode shape and voltage on the electrode,and the process of deducing the quadrupole structure and ion trap structure according to the potential distribution of the quadrupole field were discussed.In the above processes,for the purpose of binding ions,a general potential(Prof.Paul called it “allgemeinste potential” in German) distribution equation was obtained by introducing a simple harmonic motion model.And then,according to the basic laws of electromagnetic field and Maxwell's equation,the condition of zero electric field divergence was introduced.Based on this,through the discussion of the two simplest solutions and boundary conditions,the structure and field distribution equations of the quadrupole and the ion trap were obtained,respectively.This content was an important supplement to the elaboration on the theory of quadrupole field mass spectrometry,which was helpful for a deeper understanding of basic principles of quadrupole field.At the same time,this paper provided a potential mass analyzer design method.Firstly,the design began with the conception of the state of ion motion,and then a force that could control the movement of ions according to the idea was found.Secondly,combined with the basic laws of electromagnetic fields,the general equation and its limiting conditions for the potential distribution that could form this

关 键 词：质谱 四极场理论 四极杆 离子阱 

分 类 号：O657.63[理学—分析化学]