巨噬细胞钙蛋白酶促进动脉粥样硬化进展  

Macrophages calpain promotes the progression of atherosclerosis

作　　者：罗仕钰 叶世英 张雅玲 高祎 袁碧晨 孙少卫 LUO Shiyu;YE Shiying;ZHANG Yaling;GAO Yi;YUAN Bichen;SUN Shaowei(Institute of Pharmacy&Pharmacology,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学衡阳医学院药物药理研究所,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2023年第5期449-455,共7页Chinese Journal of Arteriosclerosis

基　　金：湖南省自然科学基金资助项目(2016JJ3109、2021JJ30599和2021JJ30623);湖南省大学生创新创业训练计划项目(S202110555320)。

摘　　要：动脉粥样硬化(As)是一种脂质驱动的慢性炎症性血管疾病,其发病机制以脂质代谢紊乱和炎症反应为主。钙蛋白酶(calpain)是钙离子依赖性半胱氨酸蛋白酶,研究显示其参与了As的发生发展,特别是存在于巨噬细胞中的Calpain对细胞的脂质代谢和炎症反应均有着重要调节作用。文章就巨噬细胞中Calpain参与As的可能途径及分子机制进行综述,为As的防治提供新的思路。Atherosclerosis(As)is a lipid-driven chronic inflammatory vascular disease,the pathogenesis of which primarily includes lipid metabolism disorders and inflammatory responses.Calpain,a calcium-dependent cysteine protease,has been shown to be involved in the development of As.Especially calpain in macrophages plays an important role in regulating lipid metabolism and inflammatory responses in As.This article reviews the possible pathways and molecular mechanisms of macrophages calpain involvement in As trying to provide new ideas for the prevention and treatment of As.

关 键 词：动脉粥样硬化 钙蛋白酶 巨噬细胞 脂质代谢 炎症反应 

分 类 号：R363[医药卫生—病理学] R5[医药卫生—基础医学]