血清FGF2、PTX3对妊娠期肝内胆汁淤积症的临床预测价值  

Clinical predictive value of serum FGF2 and PTX3 in intrahepatic cholestasis of pregnancy

作　　者：吕忠兴 许小燕[1] 王竹园 邢金芳[1] LV Zhong-xing;XU Xiao-yan;WANG Zhu-yuan(Department of laboratory,the Third Affiliated Hospital of Zhengzhou University,(Zhengzhou,450000),China)

机构地区：[1]郑州大学第三附属医院检验科,河南郑州450000

出　　处：《中西医结合肝病杂志》2023年第5期407-410,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河南省医学科技攻关计划(No.LHGJ20190398)。

摘　　要：目的:研究血清成纤维细胞生长因子2(FGF2)、正五聚蛋白3(PTX3)对孕产妇发生妊娠期肝内胆汁淤积症的临床预测价值。方法:收集本院2019年5月至2022年2月期间就诊的82例妊娠期肝内胆汁淤积症孕产妇为观察组研究对象,同期选取未发生妊娠期合并症的正常孕产妇78例作为对照组研究对象,收集其一般资料。采用酶联免疫吸附法检测血清FGF2、PTX3水平,采用全自动生化分析仪检测肝功能指标总胆汁酸(TBA)、总胆红素(TBil)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平;采用Pearson相关分析妊娠期肝内胆汁淤积症患者血清FGF2、PTX3水平与肝功能指标相关性;绘制受试者工作特征(ROC)曲线分析血清FGF2、PTX3水平对妊娠期肝内胆汁淤积症的预测价值;采用多因素Logistic回归分析影响妊娠期肝内胆汁淤积症的因素。结果:观察组孕妇血清FGF2、PTX3水平及TBA、TBil、ALT、AST显著高于对照组(P<0.05)。妊娠期肝内胆汁淤积症患者血清FGF2与PTX3水平呈正相关(r=0.574,P<0.05),且FGF2、PTX3与肝功能指标TBA、TBil、ALT、AST均呈正相关(P<0.05)。FGF2、PTX3及二者联合预测妊娠期肝内胆汁淤积症的ROC曲线下面积(AUC)分别为0.807、0.867、0.902,敏感度分别为75.6%、74.4%、70.7%,特异性分别为74.4%、87.2%、93.6%。FGF2、PTX3是孕产妇发生妊娠期肝内胆汁淤积症的影响因素(P<0.05)。结论:妊娠期肝内胆汁淤积症孕产妇血清FGF2、PTX3表达上调,二者对预测妊娠期肝内胆汁淤积症的发生有重要价值。Objective:To study the clinical value of serum fibroblast growth factor 2(FGF2)and pentraxin 3(PTX3)in predicting the occurrence of intrahepatic cholestasis of pregnancy in pregnant women.Methods:Eighty-two pregnant women with intrahepatic cholestasis of pregnancy who visited our hospital from May 2019 to February 2022 were collected as the research objects of the observation group.During the same course,78 normal pregnant women without pregnancy complications were regarded as the control group.Their general information was collected.Enzyme-linked immunosorbent assay was performed to detect serum FGF2 and PTX3 levels,and an automatic biochemical analyzer was applied to detect the levels of liver function indexes total bile acid(TBA),total bilirubin(TBil),alanine aminotransferase(ALT)and aspartate aminotransferase(AST).Pearson correlation was performed to analyze the correlation between serum FGF2 and PTX3 levels and liver function indexes in patients with intrahepatic cholestasis of pregnancy;receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum FGF2 and PTX3 levels for intrahepatic cholestasis of pregnancy;multivariate logistic regression analysis was performed to analyze the factors affecting intrahepatic cholestasis of pregnancy.Results:The serum levels of FGF2 and PTX3,and TBA,TBil,ALT,and AST in the observation group were significantly higher than those in the control group(P<0.05).Serum FGF2 and PTX3 levels were positively correlated in patients with intrahepatic cholestasis of pregnancy(r=0.574,P<0.05),and FGF2 and PTX3 were positively correlated with liver function indexes TBA,TBil,ALT,and AST(P<0.05).The areas under the ROC curve(AUC)of FGF2,PTX3 and their combination in predicting intrahepatic cholestasis of pregnancy were 0.807,0.867,and 0.902,respectively,with sensitivities of 75.6%,74.4%,and 70.7%,respectively,and specificities of 74.4%,87.2%,and 93.6%,respectively.FGF2 and PTX3 were the influencing factors of intrahepatic cholestasis of pregnancy in pregnant

关 键 词：妊娠期肝内胆汁淤积症 成纤维细胞生长因子2 正五聚蛋白3 预测价值 

分 类 号：R575.5[医药卫生—消化系统]