缺血性脑卒中患者外周血抗磷脂抗体、miR-125a-3p的检测及临床意义  

Detection and clinical significance of antiphospholipid antibodies and miR-125a-3pin peripheral blood of patients with ischemic stroke

作　　者：崔佳[1] 赵海利[1] 仇鹏 贾敏[1] 默海霞 CUI Jia;ZHAO Haili;QIU Peng;JIA Min;MO Haixia(Department of Clinical Laboratory,Hebei Provincial People′s Hospital,Shijiazhuang,Hebei 050051,China)

机构地区：[1]河北省人民医院检验科,河北石家庄050051

出　　处：《国际检验医学杂志》2023年第10期1219-1223,共5页International Journal of Laboratory Medicine

基　　金：河北省医学科学研究课题计划(20210778)。

摘　　要：目的 探究缺血性脑卒中(CIS)患者外周血抗磷脂抗体(aPLs)、miR-125a-3p的检测及临床意义。方法 选取2018年1月至2021年12月该院297例CIS患者为观察组,再选取同期200例健康体检者为对照组。比较两组miR-125a-3p水平及aPLs阳性率,并比较不同神经功能缺损程度患者miR-125a-3p水平及aPLs阳性率,比较不同预后患者一般资料及miR-125a-3p水平、aPLs阳性率,分析预后不良的危险因素,以及miR-125a-3p、aPLs对CIS患者预后不良的预测价值。结果 观察组血清miR-125a-3p水平、aPLs阳性率较对照组高(P<0.05);随着神经功能缺损程度增加,miR-125a-3p水平、aPLs阳性率逐渐增加(P<0.05);预后不良患者总胆固醇(TC)、甘油三酯(TG)、美国国立卫生研究院卒中量表(NIHSS)评分、miR-125a-3p、aPLs阳性率较预后良好患者高(P<0.05);miR-125a-3p水平高和aPLs阳性均为预后不良的危险因素(P<0.05);受试者工作特征(ROC)曲线显示,miR-125a-3p、aPLs联合预测CIS患者预后不良的曲线下面积(AUC)为0.859,高于单独预测(P<0.05)。结论 CIS患者miR-125a-3p水平、aPLs阳性率明显升高,且与神经功能缺损程度密切相关,且miR-125a-3p、aPLs在预后评估方面具有较好价值。Objective To investigate the detection and clinical significance of peripheral blood antiphospholipid antibodies(aPLs)and miR-125a-3p in patients with ischemic stroke(CIS).Methods A total of 297 CIS patients in our hospital from January 2018 to December 2021 were selected as the observation group,and 200 healthy subjects during the same period were selected as the control group.The level of miR-125a-3p and the positive rate of aPLs in the two groups were compared,and the levels of miR-125a-3p and the positive rate of aPLs in patients with different degrees of neurological deficit were compared.Meanwhile,the general data of patients with different prognosis and the positive rate of miR-125a-3p and aPLs were compared.The risk factors for poor prognosis were analyzed,as well as the predictive value of miR-125a-3p and aPLs for poor prognosis in CIS patients.Results The level of serum miR-125a-3p and the positive rate of aPLs in the observation group were higher than those in the control group(P<0.05);the level of miR-125a-3p and the positive rate of aPLs gradually increased with the degree of neurological deficit(P<0.05).The TC,TG,NIHSS scores,miR-125a-3p and positive rates of aPLs in patients with poor prognosis were higher than those in patients with good prognosis(P<0.05).The high level of miR-125a-3p and the positive aPLs were risk factors for poor prognosis(P<0.05).The ROC curve showed that the AUC of miR-125a-3p and aPLs combined to predict the poor prognosis of CIS patients was 0.859,which was higher than that of single prediction(P<0.05).Conclusion The level of miR-125a-3p and the positive rate of aPLs in CIS patients are significantly increased,and are closely related to the degree of neurological deficits.The miR-125a-3p and aPLs has a good value in prognostic evaluation.

关 键 词：缺血性脑卒中 抗磷脂抗体 miR-125a-3p 预后 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]