外泌体lncRNA在鳞癌中的研究进展  

Research progress of exosomal lncRNA in squamous cell carcinoma

作　　者：周兴安 苏尼特[1] 武旭 达林泰(综述)[1] 德乐黑巴特尔(审校) ZHOU Xingan;SU Nite;WU Xu;DA Lintai;DELEHEI Bateer(Department of Stomatology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China;Hohhot Stomatological Hospital)

机构地区：[1]内蒙古医科大学附属医院口腔科,呼和浩特010000 [2]呼和浩特市口腔医院

出　　处：《实用肿瘤学杂志》2023年第2期160-163,共4页Practical Oncology Journal

基　　金：内蒙古自治区自然科学基金项目(编号:2019LH08016)。

摘　　要：外泌体是由各种细胞分泌的直径为30~150 nm小囊泡,通过运输关键的蛋白质和遗传物质(如miRNA,mRNA和DNA)在细胞通讯和表观遗传调控中发挥重要作用。长链非编码RNA(long non-coding RNA,lncRNA)是一种长度超过200个核苷酸的不编码蛋白质的RNA转录物,目前研究发现lncRNA是外泌体中包含的重要核酸分子,通过外泌体介导在肿瘤发生发展和调节肿瘤生物学功能中发挥重要作用。本文将对近年来外泌体lncRNA在鳞癌(Squamous cell carcinoma,SCC)的发生发展、早期诊断、治疗与预后等方面的作用及其应用前景进行综述,以期为后续研究提供参考。Exosomes are small vesicles with a diameter of 30~150 nm secreted by various cells.They play an important role in cell communication and epigenetic regulation by transporting critical proteins and genetic materials such as miRNA,mRNA,and DNA.Long non-coding RNA(lncRNA)is an RNA transcript that is more than 200 nucleotides in length and does not encode a protein.Current studies have found that lncRNA is an important nucleic acid molecule contained in exosomes.It plays an important role in the occurrence and development of tumors,and the regulation of tumor biological function through exosome mediation.This paper reviews the development,early diagnosis,treatment and prognosis of exosome lncRNAs in squamous cell carcinoma(SCC)in recent years,as well as its application prospects,in order to provide reference for follow-up studies.

关 键 词：外泌体 长链非编码RNA 鳞状细胞癌 

分 类 号：R782[医药卫生—口腔医学]