D-生物素的高效合成研究  

Research on Efficient Synthesis of D-Biotin

作　　者：王晨光 杨士伟 束鑫 WANG Chen-guang;YANG Shi-wei;SHU Xin(Anhui Tiger Vitamin Industry Co.Ltd.,Bengbu 233700,China;Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration(Hefei Normal University),Hefei 230601,China;Anhui Fengyuan Pharmaceutical Co.Ltd.,Hefei 230601,China)

机构地区：[1]安徽泰格维生素实业有限公司,安徽蚌埠233700 [2]安徽省药食同源天然资源开发与利用工程实验室(合肥师范学院),安徽合肥230601 [3]安徽丰原药业股份有限公司,安徽合肥230601

出　　处：《安徽化工》2023年第2期57-60,共4页Anhui Chemical Industry

基　　金：合肥师范学院自然科学重点项目(2021KJZD04)。

摘　　要：以二羧酸为原料,叔胺硫酸盐或叔胺硫酸盐与硫酸的混合物为催化剂,在常压沸点>100℃的有机溶剂中回流反应,同时共沸除水,生成环酸酐;其中,所述催化剂中叔胺部分与硫酸部分的摩尔比为1∶1~1.5。本方法能够有效提高反应效率,最高收率可达99.95%,最高纯度为99.95%,同时大大降低了能耗,减少对设备的腐蚀,具有良好的工业化前景。This paper provides an preparation method of cyclic acid anhydride:using dicarboxylic acid as raw material,ter⁃tiary amine sulfate or a mixture of tertiary amine sulfate and sulfuric acid as catalyst,refluxing reaction in an organic sol⁃vent with a boiling point>100℃at normal pressure.At the same time,water is removed azeotropically to generate a cy⁃clic acid anhydride,wherein,the molar ratio of the tertiary amine part to the sulfuric acid part in the catalyst is 1∶1~1.5.This strategy can effectively improve the reaction efficiency,reduce energy consumption,and reduce the corrosion of equip⁃ment,and has a good industrialization prospect.

关 键 词：D-生物素 环酸 环酸酐 叔胺硫酸盐 三正丁胺 

分 类 号：TQ922.1[轻工技术与工程—发酵工程]