HPV生物蛋白敷料治疗宫颈癌前病变合并高危型HPV感染效果  

Effect of anti-HPV biological protein dressing for treating patients with cervical precancerous lesions complicated with high-risk human papillomavirus infection

作　　者：郭垒[1] 马艳 陈秀兰 GUO Lei;MA Yan;CHEN Xiulan(Suixi County Hospital of Traditional Chinese Medicine,Suixi,Anhui Province,235100;Anhui Huaibei Miners General Hospital)

机构地区：[1]安徽省濉溪县中医医院,235100 [2]安徽省淮北矿工总医院

出　　处：《中国计划生育学杂志》2023年第5期1047-1051,共5页Chinese Journal of Family Planning

摘　　要：目的:比较保妇康栓、辛复宁与抗HPV生物蛋白敷料治疗宫颈癌前病变合并高危型人乳头瘤病毒(HR-HPV)感染的疗效。方法:选取2019年1月-2021年5月本院收治的宫颈癌前病变合并HR-HPV感染患者212例,随机分为4组各53例,保妇康栓组给予保妇康栓经阴道给药,辛复宁组给予辛复宁经阴道给药,抗HPV敷料组给予抗HPV生物蛋白敷料经阴道给药,对照组不予处置仅定期随访。比较各组HPV转阴率及不良反应。结果:停药后1、3、6、12个月,HPV转阴率和TCT检查结果有效率保妇康栓(42.9%)、辛复宁(47.9%)与抗HPV敷料组(66.7%)均高于对照组(9.8%),且抗HPV敷料组高于保妇康栓组和辛复宁组(均P<0.05),但保妇康栓组与辛复宁组无差异(P>0.05)。阴道镜检查逆转率,保妇康栓(18.2%)、辛复宁(20.0%)与抗HPV敷料组(35.3%)高于对照组(0),且抗HPV敷料组逆转率高于保妇康栓组和辛复宁组(均P<0.05)。各组均未发生严重不良反应。结论:保妇康栓、辛复宁与抗HPV生物蛋白敷料治疗宫颈癌前病变合并HR-HPV感染均有一定疗效,抗HPV生物蛋白敷料疗效优于保妇康栓和辛复宁。Objective:To compare the efficacy of Baofukang suppository,Xinfuning,and anti-HPV biological protein dressing for treating patients with cervical precancerous lesions complicated with high risk human papillomavirus(HR-HPV)infection.Methods:A total of 212 patients with cervical precancerous lesions complicated with HR-HPV infec-tion were selected and were randomly divided into four groups(53 cases in each group)from January 2019 to May 2021.The patients in group A were treated with Baofukang suppository by vagina,the patients in group B were treated with Xinfuning by vagina,the patients in group C were treated with antir HPV biological protein dressing,and the patients in D were not given any special treatment except to regular follow-up.The HPV negative conversion rate and the ad-verse reactions rate of the patients were compared among the four groups.Results:In 1,3,6 and 12 months after drug withdrawal,the rate of HPV negative conversion and effectiveness of TCT of the patients in group A(42.9%),in group B(47.9%),or in group C(66.7%)was significantly higher than that(9.8%)of the patients in group D,and which of the patients in group C was significantly higher than that of the patients in group A or in group B(all P<0.05),but which of the patients in group A had no significantly different from that of the patients in group B(P>0.05).The reversal rate by colposcopy of the patients in group A(18.2%),in group B(20.0%),or in group C(35.3%)was significantly higher than that(0)of the patients in group D,and which of the patients in group C was significantly higher than that in group A or in group B(all P<0.05).There was no any patient with serious adverse reactions in the four groups.Conclusion:Baofukang suppository,Xinfuning,and anti-HPV biological protein dressing for treating thepatients with cervical precancerous lesions complicated with HR-HPV infection have certain efficacy,and the efficacy of anti-HPV biological protein dressing is better than that of Baofukang suppository or Xinfuning.

关 键 词：宫颈癌前病变 高危型人乳头瘤病毒 抗HPV生物蛋白敷料 保妇康栓 辛复宁 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]