宫颈癌相关基因多态性与患者报告结局和生命质量关系研究进展  

Research progress on genetic factors affecting patient-reported outcomes and quality of life in patients with cervical cancer

作　　者：陈慧艳 刘钰曦 万崇华 杨铮 谭健烽 周旋 CHEN Huiyan;LIU Yuxi;WAN Chonghua;YANG Zheng;TAN Jianfeng;ZHOU Xuan(Guangdong Medical University,Dongguan 523808,China;不详)

机构地区：[1]广东医科大学生命质量与应用心理研究中心/生命质量与心理测评干预重点实验室,广东东莞523808 [2]广东医科大学公共卫生学院,广东东莞523808

出　　处：《社区医学杂志》2023年第7期377-382,共6页Journal Of Community Medicine

基　　金：国家自然科学基金(71974040,81273185);广东省基础与应用研究重大培育项目(2017KZDXM040)。

摘　　要：整理可能对宫颈癌患者报告结局和生命质量造成影响的相关基因,并探讨这些基因多态性与患者报告结局和生命质量的关系。利用中国知网(CNKI)、万方、PubMed、ScienceDirect 4个数据库,以“宫颈癌、基因、基因多态性、情绪、心理、患者报告结局和生命质量”为中文检索词,“Cervical cancer、gene、polymorphism、emotion、psychology、patient-reported-outcomes和quality of life”为英文检索词,检索1999-01-01-2022-08-30相关文章。纳入标准:(1)基因多态性、基因与宫颈癌的相关性;(2)患者报告结局、生命质量与基因关系。排除标准:(1)年代久远的综述类文献;(2)文章质量差的文献。最终纳入文献125篇。经过专家咨询和核心小组讨论等方法筛选可能与宫颈癌患者报告结局和生命质量相关的基因,同时探讨这些基因的潜在影响机制。结果表明,脆性组氨酸三联体(FHIT)、肿瘤坏死因子(TNF)和微小RNA(miRNA)基因与宫颈癌发生发展相关;宫颈癌组中的FHIT阳性表达率较高,提示在宫颈癌中FHIT基因发生了缺失;TNF-α则可以通过其介导的凋亡相关基因单核苷酸多态性(SNP)抑制宫颈癌细胞的增殖;位于基因脆性位点或肿瘤相关基因组区域的miRNA在宫颈癌组织中的表达上调或下调等异常变化有可能在宫颈癌的致病机制中起着致癌基因或者抑癌基因的作用。5-羟色胺转运体(5-HTT)基因和多巴胺受体(DA2R)基因与宫颈癌患者心理情绪相关;5-HTT基因通过调节5-羟色胺(5-HT)的活动从而对人的情绪起到调节作用,多巴胺D2受体(DRD2)基因通过介导多巴胺的突触后活性,参与情感、情绪反应和认知功能的调节。以上结果提示,FHIT、TNF、miRNA、5-HTT基因和DA2R基因多态性可能影响宫颈癌患者报告结局和生命质量。Sorting out the related genes that may affect the reported outcome and quality of life of patients with cervical cancer, and exploring the relationship between these gene polymorphisms and the reported outcome and quality of life of patients. Using China National Knowledge Infrastructure(CNKI), Wanfang, PubMed, and ScienceDirect databases, the relevant articles from January 1, 1999 to August 30, 2022 were retrieved with the keywords of "ceramic cancer, gene, polymorphism, emotion, physiology, patient-reported-outputs, and quality of life". Literature inclusion criteria:(1)gene polymorphism, correlation between genes and cervical cancer;(2) patient-reported outcomes, quality of life and genetic relationships. Exclusion criteria:(1) old review literature;(2) literature with poor article quality. Finally, 125 literatures were included. After expert consultation and core group discussion, the genes that might be related to the reported outcome and quality of life of patients with cervical cancer were screened, and the potential influencing mechanism of these genes was also discussed. The results showed that fragile histidine triad(FHIT), tumor necrosis factor(TNF) and microRNA(miRNA) genes were related to the development of cervical cancer. The positive rate of FHIT expression in cervical cancer group was low, suggesting the deletion of FHIT gene in cervical cancer. TNF-α could inhibit the proliferation of cervical cancer cells through single nucleotide polymorphism(SNP)mediated apoptosis related gene.The abnormal changes such as up-regulated or down-regulated expression of miRNAlocated at gene brittle sites or tumor-related genomic regions in cervical cancer tissues may play the role of oncogene or tumor suppressor gene in the pathogenesis of cervical cancer.5-hydroxytryptamine transporter(5-HTT)gene and dopamine receptor(DA2R)gene were related to the psychological emotion of cervical cancer patients.The 5-HTT gene played a regulatory role in human emotions by regulating the activity of 5-HT,and the dopamine recept

关 键 词：宫颈癌 基因 心理 患者报告结局 生命质量 

分 类 号：R737.33[医药卫生—肿瘤]