卵巢癌患者血清LncRNA-MSC-AS1水平与临床病理特征及预后的关系  

Relationship between Serum LncRNA-MSC-AS1 Level and Clinicopathological Features and Prognosis in Patients with Ovarian Cancer

作　　者：李翠娥 何晓丽 何洁丽 陈贝 王燕[2] 李晶 LI Cui'e;HE Xiaoli;HE Jieli(Jianli People's Hospital,Hubei Jianli 433300,China)

机构地区：[1]湖北省监利市人民医院妇科,湖北监利433300 [2]湖北省妇幼保健院,湖北武汉437600 [3]湖北文理学院附属医院/襄阳市中心医院肿瘤科,湖北襄阳441021

出　　处：《河北医学》2023年第5期767-772,共6页Hebei Medicine

基　　金：湖北省卫生计生委科研项目,(编号:WJ2017S006)。

摘　　要：目的::探究卵巢癌(OC)患者血清长链非编码RNA肌蛋白反义RNA 1(LncRNA-MSC-AS1)水平与临床病理特征及预后的关系。方法:选自2016年11月至2018年11月本院收治的106例OC患者,即为OC组,正常的健康体检者106人为对照组,采用实时荧光定量PCR(qRT-PCR)法检测血清中LncRNA-MSC-AS1的表达水平;Kaplan-Meier生存曲线分析LncRNA-MSC-AS1表达水平与OC患者术后3年生存情况的关系;Cox回归分析影响OC患者术后3年预后不良的危险因素。结果:LncRNA-MSC-AS1在OC组(0.75±0.08)中的表达量低于对照组(1.01±0.11)(t=19.681,P<0.05);OC患者中LncRNA-MSC-AS1表达水平与TNM分期、淋巴结转移、肿瘤直径、CA125相关(P<0.05);Kaplan-Meier生存曲线分析显示,LncRNA-MSC-AS1高表达组术后3年生存率71.15%(37/52)显著高于低表达组的生存率37.04%(20/54)。(Log rank χ^(2)=12.404,P<0.001);COX回归分析显示,TNM分期、肿瘤直径、CA125、LncRNA-MSC-AS1低表达是影响OC患者术后3年预后不良的危险因素(P<0.05)。结论:LncRNA-MSC-AS1在OC患者中呈低表达,与OC患者临床病理特征及预后有关,有望成为潜在的OC预后评估生物标志物。Objective:To explore the relationship between serum long-stranded non-coding RNA myoprotein antisense RNA 1(LncRNA-MSC-AS1)level and clinicopathological features and prognosis in patients with ovarian cancer(OC).Methods:A total of 106 OC patients admitted to our hospital from November 2016 to November 2018 were taken as the OC group,and 106 normal healthy subjects were taken as the control group.The expression level of LncRNA-MSC-AS1 in serum was detected by quantitative real-time PCR(qRT-PCR);Kaplan-Meier survival curve was used to analyze the relationship between LncRNA-MSC-AS1 expression level and 3-year survival in OC patients;Cox regression analysis of risk factors affecting adverse prognosis of OC patients at 3 years after surgery.Results:The expression of LncRNA-MSC-AS1 in OC group(0.75±0.08)was lower than that in control group(1.01±0.11)(t=19.681,P<0.05);the expression level of LncRNA-MSC-AS1 in OC patients was correlated with TNM stage,lymph node metastasis,tumor diameter,and CA125(P<0.05);Kaplan-Meier survival curve analysis showed that the 3-year survival rate of the high expression group of LncRNA-MSC-AS1 was 71.15%(37/52),which was significantly higher than that of the low expression group 37.04%(20/54).(Log rank χ^(2)=12.404,P<0.001);COX regression analysis showed that TNM stage,tumor diameter,low expression of CA125 and LncRNA-MSC-AS1 were risk factors for poor prognosis of OC patients at 3 years after operation(P<0.05).Conclusion:LncRNA-MSC-AS1 is under-expressed in OC patients,which is related to the clinicopathological characteristics and prognosis of OC patients,and is expected to be a potential biomarker for OC prognosis assessment.

关 键 词：卵巢癌 长链非编码RNA肌蛋白反义RNA 1 临床病理特征 预后 

分 类 号：R737.31[医药卫生—肿瘤]