腹壁型侵袭性纤维瘤临床病理分析及TFE3蛋白在诊断中的应用  

The Clinicopathological Analysis of Aggressive Fibromatosis of Abdominal Wall and the Application of TFE3 Protein in its Diagnosis

作　　者：周百川 王刚[2] 徐阿曼[1] ZHOU Bai-chuan;WANG Gang;XU A-man(Department of General Surgery,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China;Department of General Surgery,Anhui Provincial Hospital,Hefei 230002,Anhui,China)

机构地区：[1]安徽医科大学第一附属医院普外科,安徽合肥230022 [2]安徽省立医院普外科,安徽合肥230002

出　　处：《医学信息》2023年第11期75-80,共6页Journal of Medical Information

摘　　要：目的了解腹壁型侵袭性纤维瘤(AF)的病理特征及治疗手段,探讨转录因子E3(TFE3)在诊断中的意义。方法回顾性分析安徽医科大学第一附属医院及安徽省立医院2005年3月-2021年2月收治的22例腹壁型AF患者的临床资料,并进行随访,调取其中10例切片行免疫组化验证,分析术后病理结果及β-catenin和TFE3的免疫组化染色结果。结果样本中男性2例,女性20例,均于明确诊断后接受腹壁肿物切除术。术后病理示β-catenin、SMA、Vim阳性率较高,S-100、CD34、及CD117的染色结果则多为阴性,Ki-67增殖指数均不超过10%。随访到的14例患者中术后复发3例,死亡2例。TFE3在10例免疫组化验证的患者中阳性率为90%,3例患者染色结果呈现强阳性,β-catenin的阳性率为80%,其中2例患者染色结果呈现强阳性。结论腹壁型AF属罕见的低度恶性肿瘤,复发率高,明确诊断需依赖病理检查,TFE3有潜力成为一种新兴的AF病理诊断标记物。Objective To investigate the pathological features and treatment of aggressive fibroma of abdominal wall,and to explore the significance of transcription factor E3(TFE3)in its diagnosis.Methods The clinical data of 22 patients with AF of abdominal wall admitted to the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital from March 2005 to February 2021 were retrospectively analyzed and followed up.Ten of them were taken for immunohistochemical verification.The postoperative pathological results and immunohistochemical staining results ofβ-catenin and TFE3 were analyzed.Results There were 2 males and 20 females in the sample,who underwent abdominal wall tumor resection after definite diagnosis.Postoperative pathology showed that the positive rates ofβ-catenin,SMA and Vim were high,while the staining results of S-100,CD34 and CD117 were mostly negative,and the Ki-67 proliferation index was not more than 10%.Of the 14 patients followed up,3 patients had postoperative recurrence and 2 patients were died.The positive rate of TFE3 in 10 patients verified by immunohistochemistry was 90%.The staining results of 3 patients showed strong positive,and the positive rate ofβ-catenin was 80%.Conclusion AF of abdominal wall is a rare low-grade malignant tumor with high recurrence rate.The definite diagnosis depends on pathological examination.TFE3 has the potential to become a new pathological diagnostic marker for AF.

关 键 词：腹壁型侵袭性纤维瘤 硬纤维瘤 韧带样纤维瘤 TFE3 

分 类 号：R735.5[医药卫生—肿瘤]