视神经脊髓炎谱系疾病相关神经病理性疼痛动物模型研究进展  

Research Progress on the Animal Models of Neuromyelitis Optica Spectrum Disorders⁃related Neuropathic Pain

作　　者：宋淑佳 裴丽坚[1] 徐雁[2] 张雪[1] 黄宇光[1] SONG Shujia;PEI Lijian;XU Yan;ZHANG Xue;HUANG Yuguang(Department of Anesthesiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院麻醉科,北京100730 [2]中国医学科学院北京协和医院神经科,北京100730

出　　处：《协和医学杂志》2023年第3期598-602,共5页Medical Journal of Peking Union Medical College Hospital

基　　金：中央高水平医院临床科研专项(2022-PUMCH-B-006);中央高校基本科研业务费专项基金(3332021015)。

摘　　要：视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders, NMOSD)是一种中枢神经系统炎性脱髓鞘性疾病,临床特征包括视神经炎、纵向长节段脊髓炎及其引起的疼痛,其中以神经病理性疼痛最为常见。目前已有研究证实神经病理性疼痛在NMOSD动物模型中存在,但受限于动物模型的缺乏,疼痛机制尚不明确,未来亟需建立可靠且简便易行的NMOSD神经病理性疼痛动物模型,以阐明发病机制,探索有效的预防及治疗策略。本文就NMOSD动物模型的建立及疼痛机制的研究进展作一综述,以期为建立理想的NMOSD神经病理性疼痛动物模型提供参考。Neuromyelitis optica spectrum disorders(NMOSD),an inflammatory demyelinating disease of central nervous system,is characterized by optic neuritis,longitudinally extensive transverse myelitis,and neuropathic pain.Given the lack of mature animal models,the mechanism of neuropathic pain in NMOSD is still unclear,although some studies have reported neuropathic pain in NMOSD models.It is therefore necessary to build a reliable and feasible animal model of NMOSD related neuropathic pain,in order to provide scientific support for the mechanism and the mining of therapeutic targets.This article reviews the research progress of the establishment of NMOSD⁃related neuropathic pain animal models and their applications,and provides a refer⁃ence for the establishment of ideal NMOSD neuropathic pain animal models.

关 键 词：视神经脊髓炎谱系疾病 脱髓鞘性疾病 神经病理性疼痛 动物模型 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]