儿童下颌骨低度恶性肌纤维母细胞肉瘤一例  

Low⁃grade Myofibroblastic Sarcoma of the Mandible in Children:A Case Report

作　　者：蓝育明 王芳[1] 章杰[1] LAN Yuming;WANG Fang;ZHANG Jie(Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院口腔颌面外科,南昌330006

出　　处：《协和医学杂志》2023年第3期611-616,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：国家自然科学基金(81960200,82160184);江西省自然科学基金(20224ACB206023)。

摘　　要：低度恶性肌纤维母细胞肉瘤(low-grade myofibroblastic sarcoma,LGMS)是一种极其罕见的肌成纤维细胞恶性肿瘤,好发于头颈部,口腔内常见于舌部,发生于颌骨的病例较少见,目前仅有12例报道。LGMS常发生于成年男性,儿童少见。本文报道1例罕见的下颌骨LGMS儿童病例,患儿病变累及下颌骨,行手术切除,组织病理学结果显示有梭形细胞增生并向周边横纹肌侵袭性生长;免疫组化结果显示Vimentin、Calponin、SMA和Actin呈阳性表达,支持其肌纤维母细胞和平滑肌分化的特点,诊断为LGMS。本文通过相关文献复习对颌骨LGMS的免疫学特点、病理学特征、治疗和预后进行讨论,以丰富临床医生对该病的认识,提高诊断水平。Low⁃grade myofibroblastic sarcoma(LGMS)is an extremely rare malignant tumor of myofi⁃broblastic cells that primarily affects the head and neck region.LGMS occurring in the oral cavity is commonly found on the tongue,and those occurring in the jawbone are less common,with only 12 reported cases to date.LGMS is often in adult males but rare in children.This report describes a rare case of LGMS in the mandible of a child who underwent surgical resection.Histopathological examination revealed spindle cell proliferation with invasive growth into surrounding skeletal muscle.Immunohistochemical staining showed positive expression of Vimentin,Calponin,SMA,and Actin,supporting myofibroblastic and smooth muscle differentiation of the tumor and the diagnosis of LGMS.This article,based on this case and relevant literature,discusses the immu⁃nological and pathological characteristics,treatment and prognosis of LGMS in the jawbone,in order to enrich clinicians􀆳understanding and improve the diagnosis of this disease.

关 键 词：低度恶性肌纤维母细胞肉瘤 下颌骨 颌骨 免疫组化 

分 类 号：R782[医药卫生—口腔医学] R739.8[医药卫生—临床医学]