The Role and Mechanism of LncRNA-p21 in Regulating Gastric Cancer Metastasis by Mediating Wnt/β-Catenin Signaling Pathway  

作　　者：Peng Liu Haizhe Chang Xinyu Peng Xiu Zhang Jianjun Zhang Jiusong Luan 

机构地区：[1]Emergency Medicine,Affiliated Hospital of Hebei University,Baoding 071000,China [2]Gastrointestinal Surgery,Affiliated Hospital of Hebei University,Baoding 071000,China [3]Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Hebei University,Baoding 071000,China

出　　处：《Journal of Clinical and Nursing Research》2023年第3期143-148,共6页临床护理研究（英文）

摘　　要：Objective:To study the mechanism of lncRNA p21 inhibiting the growth and metastasis of human gastric cancer SGC7901/GES-1 cells by mediating the Wnt/β-catenin signaling pathway.Methods:Lentiviral overexpression of lncRNA-p21 in human gastric cancer SGC7901/GES-1 cell transfections was observed and analyzed for in vitro migration,invasion,cell morphology and proliferation.Besides.Wnt/β-catenin signaling pathway was tested for direct involvement in lncRNA-p21-mediated inhibition of gastric cancer cell growth and proliferation.Wnt/β-catenin signaling pathway was validated using Li-C1.Results:Gastric cancer SGC7901/GES-1 cells in the overexpression of lncRNA-p21 showed changes in stellate morphology,low invasion,or spindle-shaped morphology.LncRNA-p21 inhibited the growth and proliferation of gastric cancer SGC7901/GES-1 cells both in vivo and in vitro,and Wnt/β-catenin signaling pathway mediated the proliferation,invasion,and migration of lncRNA-p21 on gastric cancer SGC7901/GES-1 cells.Conclusion:LncRNA-p21 can inhibit the growth and metastasis of gastric cancer SGC7901/GES-1 cells in vitro and in vivo,and the inhibition of lncRNA p21 is mainly mediated by inhibiting the Wnt/β-catenin signaling pathway.

关 键 词：LncRNA-p21 Wnt/beta-catenin signaling pathway Gastric cancer 

分 类 号：R73[医药卫生—肿瘤]