不同疗法对急性胰腺炎患者炎症因子和肠道黏膜功能的影响  

Effects of Different Treatments on Inflammatory Factors and Intestinal Mucosal Function in Patients with Acute Pancreatitis

作　　者：阎灿 YAN Can(Department of Gastroenterology,Daye People's Hospital,Huangshi,Hubei Province,435100 China)

机构地区：[1]大冶市人民医院消化内科,湖北黄石435100

出　　处：《中外医疗》2023年第5期85-89,共5页China & Foreign Medical Treatment

摘　　要：目的 探究急性胰腺炎患者实施急诊内科干预的作用。方法 随机选取2019年7月—2020年7月大冶市人民医院收治的100例急性胰腺炎患者为研究对象,通过随机摸红蓝球方式将所有患者划分成常规组(摸红球,50例)及观察组(摸蓝球,50例),予以常规组患者基础治疗,观察组患者在常规组的基础上给予急诊内科干预。对比治疗前后两组患者的炎性因子水平、疗效、疾病复发率以及肠道黏膜通透性情况。结果 治疗后观察组患者肿瘤坏死因子-α、白细胞介素-8和超敏C反应蛋白水平相较于常规组低,差异有统计学意义(P<0.05)。观察组治疗总有效率(96.00%)高于常规组(84.00%),差异有统计学意义(χ^(2)=4.000,P<0.05)。观察组患者疾病复发率(6.00%)低于常规组(20.00%),差异有统计学意义(χ^(2)=4.332,P<0.05)。治疗后观察组患者血二胺氧化酶以及尿乳果糖/甘露醇比值水平均低于常规组,差异有统计学意义(P<0.05)。结论 急性胰腺炎患者实施急诊内科干预,能够降低炎症水平,改善肠道黏膜通透性,增强治疗效果,降低复发率,达进而到治疗目的。Objective To explore the role of emergency medical intervention in patients with acute pancreatitis.Methods 100 patients with acute pancreatitis admitted to Daye People's Hospital from July 2019 to July 2020 were randomly selected as the research subjects.All patients were randomly divided into a routine group(50 cases touched with red and blue balls)and an observation group(50 cases touched with blue balls),and received basic treatment for the routine group patients.The observation group patients received emergency medical intervention on the basis of the routine group patients.Compared the levels of inflammatory factors,efficacy,disease recurrence rate,and intestinal mucosal permeability of the two groups of patients before and after treatment.Results After treatment,the levels of tumor necrosis factor-α,interleukin-8,and hypersensitive C-reactive protein in the observation group were lower than those in the conventional group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group(96.00%)was higher than that of the conventional group(84.00%),and the difference was statistically significant(χ^(2)=4.000,P<0.05).The disease recurrence rate in the observation group(6.00%)was lower than that in the conventional group(20.00%),and the difference was statistically significant(χ^(2)=4.332,P<0.05).After treatment,the levels of blood diamine oxidase and urine lactulose/mannitol ratio in the observation group were lower than those in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Implementing emergency medical intervention in patients with acute pancreatitis can reduce inflammation levels,improve intestinal mucosal permeability,enhance treatment effectiveness,reduce recurrence rates,and ultimately achieve treatment goals.

关 键 词：肠道黏膜通透性 急性胰腺炎 内科治疗 急诊 炎症因子 

分 类 号：R576[医药卫生—消化系统]