传统输液疗法与GDFT治疗对结肠癌手术治疗患者胃肠功能及临床指标的影响对比  

Comparison of the Effects of Traditional Infusion Therapy and GDFT Treatment on Gastrointestinal Function and Clinical Indicators in Patients Undergoing Surgery for Colon Cancer

作　　者：侯建彬 李新宇[1] 陈琦玮 HOU Jianbin;LI Xinyu;CHEN Qiwei(Department of Gastrointestinal Surgery,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou,Fujian Province,362000 China)

机构地区：[1]福建医科大学附属泉州第一医院胃肠外科,福建泉州362000

出　　处：《中外医疗》2023年第4期95-98,103,共5页China & Foreign Medical Treatment

摘　　要：目的分析传统输液疗法与目标导向液体治疗(goal-directed fluid therapy,GDFT)对结肠癌手术治疗患者胃肠功能及临床指标的影响。方法选取2019年1月—2021年12月期间于福建医科大学附属泉州第一医院实施手术的200例结肠癌患者为研究对象,依据患者的液体治疗方式将其分为观察组(100例)和对照组(100例),分别采用传统输液疗法、GDFT治疗。比较两组患者治疗效果。结果手术前,观察组胃动素为(268.25±11.53)pg/mL、5-羟色胺为(117.26±10.71)ng/L、胃泌素为(24.18±1.68)pg/mL,对照组胃动素为(269.57±11.66)pg/mL、5-羟色胺为(117.33±10.65)ng/L、胃泌素为(24.22±1.73)pg/mL,两组胃动素、5-羟色胺、胃泌素水平相比,差异无统计学意义(t=0.805、0.046、0.166,P=0.422、0.963、0.868);手术后,观察组胃动素为(322.47±14.18)pg/mL、5-羟色胺(81.39±8.23)ng/L、胃泌素(28.08±0.82)pg/mL,对照组胃动素为(302.18±13.69)pg/mL、5-羟色胺(93.37±9.68)ng/L、胃泌素(26.25±1.01)pg/mL,观察组胃动素、5-羟色胺、胃泌素水平均优于对照组,差异有统计学意义(t=10.294、9.429、14.067,P<0.001)。观察组血流动力学指标和生化指标均优于对照组,差异有统计学意义(P<0.05)。结论采用GDFT治疗更有利于改善结肠癌手术治疗患者的胃肠功能、血流动力学指标及生化指标。Objective To analyze the effects of traditional infusion therapy and goal-directed fluid therapy(GDFT)on gastrointestinal function and clinical indexes of patients treated surgically for colon cancer.Methods A total of 200 patients with colon cancer who underwent surgery in Quanzhou First Hospital Affiliated to Fujian Medical University from January 2019 to December 2021 were selected as the study objects.Patients were divided into observation group(100 cases)and control group(100 cases)according to their fluid treatment methods,and were treated with traditional infusion therapy or GDFT therapy,respectively.The therapeutic effect of the two groups was compared.Results Before operation,motilin,5-hydroxytryptamine and gastrin in the observation group were(268.25±11.53)pg/mL,(117.26±10.71)ng/L,(24.18±1.68)pg/mL respectively,and motilin,5-hydroxytryptamine and gastrin in the control group were(269.57±11.66)pg/mL,(117.33±10.65)ng/L,(24.22±1.73)pg/mL,respectively.There was no statistically significant difference in the levels of motilin,penta and gastrin between the two groups(t=0.805,0.046,0.166,P=0.422,0.963,0.868).After operation,in the observation group,motilin was(322.47±14.18)pg/mL,5-hydroxytamine was(81.39±8.23)ng/L,gastrin was(28.08±0.82)pg/mL,and motilin,5-hydroxytry ptamine and gastrin in the control group were(302.18±13.69)pg/mL,(93.37±9.68)ng/L,(26.25±1.01)pg/mL,the levels of motilin,5-hydroxytryptamin and gastrin in the observation group were better than those in the control group,and the difference was statistically significant(t=10.294,9.429,14.067,P<0.001).The hemodynamic indexes and biochemical indexes in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of GDFT treatment is more beneficial to improve the gastrointestinal function,hemodynamic indexes and biochemical indexes of patients treated with colon cancer surgery.

关 键 词：结肠癌手术 GDFT 胃肠功能 

分 类 号：R735.35[医药卫生—肿瘤]