保乳手术与改良根治术对中青年乳腺癌术后预后的影响  

Effect of Breast-conserving Surgery and Modified Radical Surgery on Postoperative Prognosis of Middle-aged and Young Adults with Breast Cancer

作　　者：杨炳林 肖坚 陈文新 王合兵 陈基铖 张茂泉 YANG Binglin;XIAO Jian;CHEN Wenxin;WANG Hebing;CHEN Jicheng;ZHANG Maoquan(Department of Mammography,Sanming First Hospital Affiliated to Fujian Medical University,Sanming,Fujian Province,365000 China)

机构地区：[1]福建医科大学附属三明第一医院乳腺科,福建三明365000

出　　处：《中外医疗》2023年第4期99-103,共5页China & Foreign Medical Treatment

摘　　要：目的分析中青年乳腺癌患者应用保乳手术与改良根治术的临床有效性,以及术后预后的影响。方法选取2020年1—12月福建医科大学附属三明第一医院乳腺科收治的中青年乳腺癌患者80例为研究对象,应用随机数表法分成两组,每组40例。比照组采用改良根治术治疗,研究组采用保乳手术治疗。对比和分析手术各项结果。结果研究组切口长度(5.50±3.72)cm、手术时间(81.80±8.70)min、出血量(40.22±5.78)mL、术后引流量(51.00±15.43)mL、住院时间(7.00±2.71)d均优于比照组,差异有统计学意义(t=9.755、16.690、26.168、16.630、6.886,P<0.001)。研究组并发症发生率低于比照组,差异有统计学意义(P<0.05)。手术前1 d,两组丙二醛、超氧化物歧化酶数据比较,差异无统计学意义(P>0.05);手术后3 d,研究组丙二醛低于比照组,超氧化物歧化酶高于比照组,差异有统计学意义(P<0.05)。手术前1 d,两组TNF-α、CRP、IL-6、IL-10比较,差异无统计学意义(P>0.05);手术后3 d,研究组TNF-α,CRP,IL-6水平均低于比照组,IL-10水平高于比照组,差异有统计学意义(P<0.05)。结论中青年乳腺癌患者应用保乳手术效果更为显著,对患者造成的创伤以及应激反应较少。Objective To analyze the clinical effectiveness of breast-conserving surgery versus modified radical surgery applied to middle-aged and young breast cancer patients,and the impact of postoperative prognosis.Methods A total of 80 middle-aged and young patients with breast cancer admitted to the Breast Department of the Sanming First Hospital Affiliated to Fujian Medical University from January to December 2020 were selected as the research objects.They were divided into two groups by random number table method,with 40 cases in each group.The comparison group was treated with modified radical operation,and the study group was treated with breast-conserving operation.The results of operation were compared and analyzed.Results Incision length(5.50±3.72)cm,operation time(81.80±8.70)min,blood loss(40.22±5.78)mL,postoperative drainage volume(51.00±15.43)mL and hospital stay(7.00±2.71)d in the study group were all better than those in the comparison group,and the difference was statistically significant(t=9.755,16.690,26.168,16.630,6.886,P<0.001).The incidence of complications in the study group was lower than that in the comparison group,and the difference was statistically significant(P<0.05).1 d before operation,there was no statistically significant difference in the data of malondialdehyde and superoxide dismutase between the two groups(P>0.05).3 days after operation,malondialdehyde in the study group was lower than that in comparison group,and superoxide dismutase was higher than that in comparison group,the difference was statistically significant(P<0.05).1 d before operation,there were no statistically significant differences in TNF-α,CRP,IL-6 and IL-10 between the two groups(P>0.05).3 days after operation,the levels of TNF-α,CRP and IL-6 in the study group were lower than those in the control group and IL-10 was higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion The application of breast-conserving surgery in young and middle-aged breast cancer patients

关 键 词：保乳手术 改良根治术 中青年 乳腺癌 术后 预后 

分 类 号：R737[医药卫生—肿瘤]