SREBP1在肿瘤发生发展中的作用  

Roles of SREBP1 in the oncogenesis and development of tumors

作　　者：陈欣德 徐煜周 周帅 张茂容 李璐[1,3] 吴东婷 吴志浩 CHEN Xinde;XU Yuzhou;ZHOU Shuai;ZHANG Maorong;LI Lu;WU Dongting;WU Zhihao(Research Laboratory of Tumor Microenvironment,Wannan Medical College,Wuhu 241002,China;School of Preclinical Medicine,Wannan Medical College,Wuhu 241002,China;School of Clinical Medicine,Wannan Medical College,Wuhu 241002,China;School of Anesthesiology,Wannan Medical College,Wuhu 241002,China;School of Imaging,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院肿瘤微环境研究室,安徽芜湖241002 [2]皖南医学院基础医学院,安徽芜湖241002 [3]皖南医学院临床医学院,安徽芜湖241002 [4]皖南医学院麻醉学院,安徽芜湖241002 [5]皖南医学院影像学院,安徽芜湖241002

出　　处：《沈阳医学院学报》2023年第3期301-305,共5页Journal of Shenyang Medical College

基　　金：国家自然科学基金项目(No.81872371);安徽省自然科学基金项目(No.1708085MH203);分子肿瘤学国家重点实验室开放课题(No.SKL-KF-2019-11)。

摘　　要：甾醇调节原件结合蛋白1(sterol regulatory element binding protein 1,SREBP1)是脂质合成代谢中的关键蛋白,能够促进细胞中脂质合成基因的转录,进而促进脂质合成,在能量供应及储存、细胞膜与细胞器膜的构建等方面发挥重要作用。脂质代谢异常与肿瘤的发生密切相关,近年来研究发现,SREBP1在肿瘤中异常高表达,与肿瘤的发生发展密切相关。本文主要对SREBP1的结构、功能,及其在肿瘤发生发展中的作用及机制进行综述,为肿瘤的基础研究及临床治疗提供新的思路和潜在的治疗靶点。Sterol regulatory element binding protein 1(SREBP1)is a key protein in lipid metabolism,which can promote the transcription of lipid synthesis-related genes and thus promote lipid synthesis.It plays an important role in energy supply and storage,and construction of cell membrane and organelle membrane.The occurrence of tumor is often accompanied by abnormal lipid metabolism.Recent studies have found that SREBP1 is abnormally high expressed in tumors,which is closely related to the occurrence and development of tumors.This paper reviews the structure and function of SREBP1,as well as its role in the occurrence and development of tumors,providing new ideas and potential therapeutic targets for basic research and clinical treatment of tumors.

关 键 词：甾醇调节原件结合蛋白1 脂质代谢 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]