奥氮平联合阿扎司琼对癌症合并糖尿病化疗止吐的疗效观察  

Observe the efficacy of Olanzapine combined with Azasetron in the treatment of chemotherapy induced nausea and vomiting in patients with cancer complicated with diabete mellitus

作　　者：崔虎军 胡彬 王敏 郭文文 张兆国 黄艳超 CUI Huyjun;HU Bin;WANG Min;GUO Wenen;ZHANG Zhaoguo;HUANG Yancha(Department of Oncology,Hongqi Hospial Afliated 1o Mudanjiang Medical College,Mudanjiang 157011,Heilongjiang.Chira)

机构地区：[1]牡丹江医学院附属红旗医院肿瘤科,157011

出　　处：《中国老年保健医学》2023年第2期71-73,共3页Chinese Journal of Geriatric Care

基　　金：牡丹江市科学技术计划项目(合同编号:Z217s0058)。

摘　　要：目的观察奥氮平联合阿扎司琼治疗癌症合并糖尿病患者化疗导致恶心呕吐的疗效。方法采用随机对照研究方法,将57例接受中-高致吐化疗药物治疗的患者分为观察组和对照组。观察组28例,止吐方案采用奥氮平联合阿扎司琼;对照组29例,止吐方案采用阿扎司琼联合地塞米松。对比两组化疗所致恶心呕吐(CINV)发生情况、止吐效果及两组患者化疗期间血糖变化情况。结果观察组恶心呕吐完全缓解率为28.60%,略低于对照组恶心呕吐完全缓解率31.00%,P>0.05,差异无统计学意义。观察组恶心呕吐控制有效率为60.70%,略低于对照组恶心呕吐控制有效率65.50%,P>0.05,差异无统计学意义。观察组连续3天血糖无明显变化,差异无统计学意义。对照组第二天血糖较第一天升高,但差异无统计学意义(P>0.05)。第三天血糖较第一天升高,t=-2.014,P=0.049,差异有统计学意义。结论奥氮平联合阿扎司琼治疗化疗所致恶心呕吐疗效较好,可以替代地塞米松,避免了癌症合并糖尿病患者化疗期间因地塞米松所致血糖升高的风险。Objective To observe the efficacy of Olanzapine combined with Azasetron in the treatment of chemotherapy induced nausea and vomiting(CINV)in patients with cancer complicated with diabetes mellitus.Methods In a randomized controlled study,57 patients who received moderate to high emetic chemotherapeutic drugs were divided into observation group and control group.In the observation group,28 cases were treated with Olanzapine combined with Azasetron in the control group,29 cases were treated with Azasetron combined with Dexamethasone.The occurrence and antiemetic effect of chemotherapy induced nausea and vomiting(CINV)and the changes of blood glucose during chemotherapy were compared between the two groups.Results The complete remission rate of CINV in the observation group was 28.60%,which was slightly lower than that in the control group(31.00%),the difference was not statistically significant(P>0.05).The effective rate of CINV control in the observation group was 60.70%,which was slightly lower than that in the control group(65.50%),the difference was not statistically significant(P>0.05).There was no significant change in blood glucose in the observation group for three consecutive days,the difference was not statistically significant.The blood glucose of the control group on the second day was higher than that on the first day,but the difference was not statistically significant(P>0.05).The blood glucose on the third day was higher than that on the first day,and the difference was statistically significant(t=-2.014,P=0.049).Conclusion Olanzapine combined with Azasetron is effective in the treatment of chemotherapy induced nausea and vomiting,which can replace Dexamethasone and avoid the risk of elevated blood sugar caused by Dexamethasone during chemotherapy in patients with cancer complicated with diabetes mellitus.

关 键 词：奥氮平 癌症合并糖尿病 化疗 恶心呕吐 

分 类 号：R73[医药卫生—肿瘤] R587.2[医药卫生—临床医学]