丁苯酞联合溶栓对减轻老年人急性脑梗死神经功能缺损程度的研究  

The Study of Butylphthalide Combined With Thrombolysis on Reducing Neurological Deficits in the Elderly With Acute Cerebral Infarction

作　　者：周继武 李超 ZHOU Jiwu;LI Chao(Department of Emergency Medicine,the People’s Hospital of Xintai City,Xintai Shandong 271200,China)

机构地区：[1]新泰市人民医院急诊医学科,山东新泰271200

出　　处：《中国卫生标准管理》2023年第9期129-132,共4页China Health Standard Management

摘　　要：目的 探究丁苯酞联合溶栓治疗老年急性缺血性脑梗死的效果。方法 选取2021年8月—2022年7月新泰市人民医院急诊医学科收治的120例老年急性缺血性脑梗死患者,经随机分组,对照组(n=60)予以超早期阿替普酶静脉溶栓治疗,观察组(n=60)在此基础上结合丁苯酞静脉滴注治疗,比较两组临床疗效、神经功能缺损程度、生活质量及不良事件发生率。结果 观察组和对照组总有效率分别为88.33%、66.67%,差异有统计学意义(P <0.05)。观察组治疗后美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分低于对照组(P <0.05)。随访1个月观察组Barthel指数高于对照组(P <0.05)。观察组和对照组不良事件总发生率分别为11.67%、26.67%,差异有统计学意义(P <0.05)。结论 丁苯酞联合溶栓治疗老年急性缺血性脑梗死患者的疗效确切,有助于减轻神经功能缺损程度,提高生活质量,且治疗安全可靠。Objective To explore the effect of butylphthalide combined with thrombolysis in the treatment of acute ischemic cerebral infarction in the elderly.Methods A total of 120 elderly patients with acute ischemic cerebral infarction admitted to the department of emergency medicine,the People’s Hospital of Xintai City from August 2021 to July 2022 were randomly divided into two groups.The control group(n=60)was treated with ultra-early intravenous thrombolysis with alteplase,and the observation group(n=60)was treated with intravenous infusion of butylphthalide.The clinical efficacy,degree of neurological impairment,quality of life,and incidence of adverse events were compared between the two groups.Results The total effective rates of the observation group and the control group were 88.33%and 66.67%,the difference was statistically significant(P<0.05).The National Institute of Health Stroke Scale(NIHSS)score of the observation group after treatment was lower than that of the control group(P<0.05).Following up for one month,the Barthel index of the observation group was higher than that of the control group(P<0.05).The total adverse event rates in the observation group and the control group were 11.67%and 26.67%,the difference was statistically significant(P<0.05).Conclusion Butylphthalide combined with thrombolytic therapy is effective in the treatment of elderly patients with acute ischemic cerebral infarction,which is helpful to reduce the degree of neurological impairment and improve the quality of life,and the treatment is safe and reliable.

关 键 词：丁苯酞 超早期溶栓治疗 老年 急性缺血性脑梗死 治疗效果 神经功能 安全性 

分 类 号：R741[医药卫生—神经病学与精神病学]