中青年与老年胃食管反流病患者内镜射频治疗的疗效分析  

Efficacy and prognosis of endoscopic radiofrequency therapy in GERD patients with different ages

作　　者：高岩[1] 邓宛青 魏雪 卢迪[1] 钱洁 尚占民[1] 郝建宇[1] Gao Yan;Deng Wanqing;Wei Xue;Lu Di;Qian Jie;Shang Zhanmin;Hao Jianyu(Department of Gastroenterology,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院消化内科,北京100020

出　　处：《中国医刊》2023年第6期626-629,共4页Chinese Journal of Medicine

摘　　要：目的 比较中青年与老年胃食管反流病(gastroesophageal reflux disease,GERD)患者行内镜射频治疗的疗效。方法 选取2017年2月至2022年9月于首都医科大学附属北京朝阳医院接受内镜射频治疗的54例GERD患者,根据年龄分为中青年组(<60岁)34例和老年组(≥60岁)20例。收集两组患者临床资料,以及射频治疗前和治疗后3个月、6个月时的胃食管反流病问卷(gastroesophageal-reflux disease questionnaire,Gerd Q)评分和质子泵抑制剂(proton pump inhibitors,PPI)使用情况等并进行比较。结果 射频治疗后3个月及6个月时,两组患者的Gerd Q评分均较治疗前显著降低,且中青年组明显低于老年组,差异有显著性(P<0.01)。在射频治疗后3个月,中青年组和老年组分别有94.1%和80.0%的患者减少PPI用量,射频治疗后6个月,中青年组和老年组分别有88.2%和70.0%的患者减少PPI用量,中青年组减少PPI用量的比例与老年组比较差异无显著性(P>0.05)。两组患者均无严重并发症发生。结论 中青年及老年GERD患者行内镜射频治疗均可改善Gerd Q评分,减少PPI用量,该疗效可维持至射频治疗后6个月,安全性较好,且中青年患者的疗效优于老年患者。Objective Compare the efficacy of endoscopic RF therapy in patients with gastroesophageal reflux disease(GERD)in young and elderly groups.Method 54 GERD patients receiving endoscopic radiofrequency therapy in Beijing Chao-yang Hospital from February 2017 to September 2022were selected.According to their age,they were divided into young groups which younger than 60 years(34 cases)and elder groups which older than 60 years(20 cases).The gastroesophageal reflux disease questionnaire scale(GerdQ)and the use of proton pump inhibitors(PPI)were collected before and 6 months after RF treatment,and compared the indicators before and at 3,6 months after endoscopic RF therapy.The efficacy of endoscopic radiofrequency therapy was evaluated by comparing the indexes before and after endoscopic radiofrequency therapy in each group of patients.Result After 3 months and 6 months of RF treatment,the GerdQ scores of the young and elderly group were significantly lower than before RF treatment(P<0.05);and the GerdQ score in the young group was lower(P<0.01).At 3 months after RF treatment,94.1%of patients in the young group and 80.0%in the elderly group decreased PPI use,6 months after RF treatment,88.2%of patients in the young group and 70.0%in the elderly group decreased PPI use,and the proportion of PPI reduction in the younger group was not significant compared with the elderly group(P>0.05).Conclusion Endoscopic radiofrequency therapy can improve GerdQ scores and reduce PPI use in GERD patients,which can be maintained until 6 months after RF with good safety.The younger group(<60 years)may have a better prognosis than the older group(≥60 years).

关 键 词：胃食管反流病 年龄 内镜治疗 射频治疗 

分 类 号：R573[医药卫生—消化系统]