曲克芦丁联合丁苯酞治疗脑梗死的临床疗效评价  

Clinical efficacy evaluation of troxerutin combined with butylphthalide in the treatment of cerebral infarction

作　　者：刘冠雄 朱风俊[1] 徐明超[1] 樊书领[1] 金鑫 贾东佩[1] Guan-Xiong LIU;Feng-Jun ZHU;Ming-Chao XU;Shu-Ling FAN;Xin JIN;Dong-Pei JIA(Department of Neurology(Department of Rehabilitation Medicine),Nanyang Central Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳市中心医院神经内科(康复医学科),河南南阳473000

出　　处：《数理医药学杂志》2023年第5期370-376,共7页Journal of Mathematical Medicine

摘　　要：目的 探讨曲克芦丁联合丁苯酞治疗脑梗死患者的临床疗效。方法 选取2020年2月至2022年4月南阳市中心医院收治的98例脑梗死患者作为研究对象,按照治疗方式差异将其分为观察组(51例)和对照组(47例),对照组予以丁苯酞治疗,观察组在此基础上联合曲克芦丁治疗。比较两组在疗效、不良反应发生率、治疗前后神经功能、日常生活能力、凝血功能(D-二聚体,D-D)、凝血酶原时间(PT)、纤维蛋白原(FIB)及一氧化氮(NO)、内皮素-1(ET-1)和血管性假血友病因子(vWF)水平的差异。结果 观察组总有效率较对照组高(98.04%vs. 76.60%,P<0.001);在神经功能方面,治疗后两组NIHSS评分下降,观察组较对照组低(7.38±2.33vs. 12.78±2.75,P <0.001),两组BI评分升高,观察组较对照组高(58.01±10.72vs. 46.45±8.35,P <0.001);在凝血功能方面,两组治疗后D-D、PT、FIB、NO、ET-1、vWF水平均改善,观察组优于对照组(P <0.05)。结论 曲克芦丁联合丁苯酞可能有助于调节脑梗死患者的NO、ET-1、vWF水平,改善神经功能、日常生活能力与凝血功能,对于治疗脑梗死具有一定的价值。Objective To investigate the clinical treatment effect of troxerutin combined with butylphthalide in the treatment of patients with cerebral infarction.Method 98 patients with cerebral infarction admitted to Nanyang Central Hospital from February 2020 to April 2022 were selected,and were divided into observation group(n=51)and control group(n=47)according to the treatment methods.The control group was treated with butylphthalide,and the observation group was treated with troxerutin on the basis of control group.The differences in efficacy,incidence of adverse effects,neurological function,ability to perform daily living,coagulation function(D-dimer,D-D),prothrombin time(PT),fibrinogen(FIB),nitric oxide(NO),endothelin-1(ET-1)and vascular pseudohemophilic factor(vWF)levels before and after treatment in the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(98.04%vs.76.60%,P<0.05).In terms of neurological function,after treatment,the NIHSS score of the two groups decreased,the observation group was lower than the control group(7.38±2.33 vs.12.78±2.75,P<0.001),the BI score of the two groups increased,and the study group was higher than the control group(58.01±10.72 vs.46.45±8.35,P<0.001).In terms of coagulation function,the levels of D-D,PT,FIB,NO,ET-1 and vWF in the two groups were improved after treatment,and the levels in the observation group were better than those in the control group(P<0.05).Conclusion The combination of troxerutin and butylphthalide may help regulate the levels of NO,ET-1 and vWF in patients with cerebral infarction,improve neurological function,daily living ability and coagulation function,and has certain reference value for the treatment of cerebral infarction.

关 键 词：曲克芦丁 丁苯酞 脑梗死 神经功能 凝血功能 血管内皮功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]