阿尔茨海默病患者血清中TREM-1浓度水平及诊断效能  

Expression and Diagnostic Value of TREM-1 in Patients with Alzheimer′s Disease

作　　者：王炜杰 徐宇浩[1] 党玉婷 周亚丽 于明[1] WANG Weijie;XU Yuhao;DANG Yuting(Department of Neurology,Affiliated Hospital of Jiangsu University,Jiangsu 212000,China)

机构地区：[1]江苏大学附属医院神经内科,镇江212000

出　　处：《医学研究杂志》2023年第5期48-50,共3页Journal of Medical Research

基　　金：国家自然科学基金资助项目(82101431);江苏省镇江市社会发展科技计划项目(SH2019036)。

摘　　要：目的探讨阿尔茨海默病(Alzheimer′s disease,AD)患者血清中髓样细胞触发受体-1(triggering receptor expressed on myeloid cells-1,TREM-1)的表达水平及临床诊断价值。方法收集2021年1~6月就诊于江苏大学附属医院神经内科门诊的40例AD患者为AD组,另选取20例健康体检者为对照组。AD组和对照组在入组时采用ELISA试剂盒检测血清中TREM-1的浓度,采用MMSE量表评价患者的认知功能,分析血清TREM-1浓度与简易精神状态检查(mini-mental state examination,MMSE)量表评分的相关性,ROC曲线评价TREM-1对AD的诊断效能。结果AD组血清TREM-1浓度高于对照组;与MMSE呈负相关(r=-1.025,P<0.01);ROC曲线结果显示血清TREM-1曲线下面积为0.874(P<0.01),敏感度为75.0%,特异性为87.5%。结论AD患者血清中TREM-1表达升高,可作为AD诊断的生物学标志物。Objective To discuss the expression level and clinical diagnostic value of TREM-1 in serum of patients with Alzheimer′s disease(AD).Methods From January 2020 to June 2020,40 patients with initial diagnosis in the Department of Neurology of Jiangsu University Affiliated Hospital were collected as AD groups,and 20healthy examinees were selected as control groups.The expres-sion level of TREM-1 was detected by ELISA KitⅠfor AD group and control group.The cognitive function of AD patients was evaluated by the mini-mental state examination(MMSE).The correlation between the expression level of serum TREM-1 and the scores of MMSE were analyzed.The diagnostic efficacy of TREM-1 for AD was evaluated by receiver operating characteristic(ROC)curves.Results The serum TREM-1 concentration of patients in the AD group was higher than that in the control group,with statistically significant differences(P<0.05).There was significant negative correlation between expression level of serum TREM-1 and MMSE(r=-1.015).The ROC curve showed that the area under the curve of serum TREM-1 was 0.874(P<0.01).Conclusion The expres-sion of serum TREM-1 is up-regulated in AD patients and is expected to be used as a biological marker for early diagnosis of AD.

关 键 词：阿尔茨海默病 TREM-1 血清 生物学标志物 

分 类 号：R741.04[医药卫生—神经病学与精神病学]