Research on GGT-responsive drug carrier with active transport effect  

作　　者：Han Yan He Ma Bin He Bing Yu Youqing Shen Hailin Cong 

机构地区：[1]Institute of Biomedical Materials and Engineering,College of Materials Science and Engineering,College of Chemistry and Chemical Engineering,Qingdao University,Qingdao 266071,China [2]State Key Laboratory of Bio-Fibers and Eco-Textiles,Qingdao University,Qingdao 266071,China [3]Key Laboratory of Biomass Chemical Engineering of Ministry of Education,Center for Bionanoengineering,Department of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China [4]School of Materials Science and Engineering,Shandong University of Technology,Zibo 255000,China

出　　处：《Nano Research》2023年第5期7075-7084,共10页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21874078,22074072,and 22274083);the Exploration project of the State Key Laboratory of Bio-Fibers and Eco-Textiles of Qingdao University(No.TSKT202101);the High Level Discipline Project of Shandong Province,the Innovation and Development Joint Fund of Natural Science Foundation of Shandong Province(ZR2022LZY022);the Science and Technology Planing Project of South District of Qingdao City(2022-4-005-YY).

摘　　要：Although a great quantity research has been done on cancer nano-drug carriers,how to deliver more cancer nano-drugs to tumor sites accurately and then endocytosis by cells is still a key problem in the process of cancer treatment.Since the concentration ofγ-glutamyl transpeptidase(GGT)in the microenvironment will be greatly increased when the liver,kidney,other organs become cancerous,we have designed a polymer nanomicelle as drug carrier that can respond to the GGT in the tumor microenvironment.When the drug delivery system participates in blood circulation through the vascular wall cells to the tumor tissue,the overexpressed GGT on the surface of the cancer cells will recognize and cut theγ-glutamyl group on the carrier,the primary amines will be released to make the system with weak positive charge,which not only improves the carrier’s active transport ability for nanodrugs,but also improves the cell’s endocytosis ability for nano-drugs,so as to realize the release of nano-drugs in cancer cells.What’s more,the positive charge on the surface of the carrier also improves the permeability of the carrier in the tumor tissue,so that the cancer cells in the hypoxic area can also endocytosis drugs.

关 键 词：micelles enzyme response active transport ENDOCYTOSIS 

分 类 号：TB383[一般工业技术—材料科学与工程]