Carvacrol combined with NIR light-responsive nano-drug delivery system with specific anti-bacteria,anti-inflammation,and immunomodulation for periodontitis  

作　　者：Daorun Hu Congkai Zhang Chao Sun Haijing Bai Jialiang Xie Yawen Gu Mengyuan Li Junkai Jiang Aiping Le Jiaxuan Qiu Xiaolei Wang 

机构地区：[1]Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China [2]The National Engineering Research Center for Bioengineering Drugs and the Technologies,Institute of Translational Medicine,Nanchang University,Nanchang 330088,China [3]Department of Transfusion Medicine,The First Affiliated Hospital of Nanchang University,Key Laboratory of Jiangxi Province for Transfusion Medicine,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China [4]College of Chemistry and Chemical Engineering,Nanchang University,Nanchang 330088,China

出　　处：《Nano Research》2023年第5期7199-7215,共17页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.31860263,81860477,32071223,and 82260194);Key Youth Project of Jiangxi Province(No.20202ACB216002);Key Research and Development Program of Jiangxi Province(Nos.20212BBG73004,20212BBG71005,and 20192ACB50014);the Local Science and Technology Development Fund(No.20221ZDG020068);Key Laboratory of Jiangxi Province for Transfusion Medicine(No.20212BCD42006);Graduate Innovative Special Fund Projects of Jiangxi Province(Nos.YC2021-B045 and YC2021-B057).

摘　　要：Bacterial infection,biofilm formation,immune dysfunction are common triggers and aggravators in periodontitis,which render periodontal restoration challenging.Thus,a strategy with antibacterial,anti-inflammatory,immunoregulatory capacities has great promise in the clinical practice of periodontitis.Herein,carvacrol(CA)-based near-infrared(NIR)lightresponsive nano-drug delivery system is developed for the first time.The system consists of upconversion nanoparticles(UCNPs,which upconvert 808 nm NIR to blue light),mesoporous silica(mSiO_(2),the carrier channel),hydrophobic CA(blue light response properties).Under the irradiation of 808 nm NIR,owing to the synergy of CA and upconverted blue light,the UCNPs@mSiO_(2)-CA(UCMCs)exhibit the properties of specific anti-bacteria(including anaerobic bacteria),anti-inflammation,and immunomodulation.Notably,high-throughput sequencing results exhibit that many classic inflammatory immune-related signaling pathways,including the MAPK signaling pathway,tumor necrosis factor(TNF)signaling pathway,IL-17 signaling pathway,are enriched to remodel the immune microenvironment.Additionally,UCMCs with NIR irradiation accelerate periodontal restoration and serve as promising non-invasive management of periodontitis.Altogether,this study verifies the feasibility of herbal monomer combined with light-responsive in situ nano-drug delivery system and provides a more effective and reliable strategy for various potential applications of deep tissue diseases.

关 键 词：ANTI-BACTERIA near-infrared light upconversion nanoparticle PERIODONTITIS drug delivery 

分 类 号：TB383[一般工业技术—材料科学与工程] R781.42[医药卫生—口腔医学]