宫颈癌患者血清FOXQ1和CEACAM19表达水平检测的临床早期诊断价值研究  

Study on the Clinical Early Diagnostic Value of Serum FOXQ1 and CEACAM19 Expression Levels in Patients with Cervical Cancer

作　　者：邹清靖 陈燕[1] 吴小玲[1] 居文惠[1] ZOU Qing-jing;CHEN Yan;WU Xiao-ling;JU Wen-hui(Department of Gynaecology,Jingzhou Central Hospital,Hubei Jingzhou 434000,China)

机构地区：[1]荆州市中心医院妇科,湖北荆州434000

出　　处：《现代检验医学杂志》2023年第3期154-158,共5页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨血清叉头框蛋白Q1(fork-head box Q1, FOXQ1)和癌胚抗原相关细胞黏附分子19(carcinoembryonic antigen-related cell adhesion molecule 19, CEACAM19)联合检测对宫颈癌的早期诊断价值。方法 选取2019年1月~2022年8月荆州市中心医院收治的120例宫颈癌患者、120例宫颈上皮内瘤变(cervical intraepithelial neoplasias, CIN)患者分别为宫颈癌组、CIN组,另选取同期120例健康体检者为健康组。比较宫颈癌组、CIN组和健康组血清FOXQ1,CEACAM19水平;分析血清FOXQ1,CEACAM19水平与宫颈癌临床病理特征的关系;受试者工作特征(receiver operating characteristic, ROC)曲线分析血清FOXQ1和CEACAM19对宫颈癌的早期诊断价值;Logistic回归分析宫颈癌发生的影响因素。结果 与健康组比较,CIN组和宫颈癌组血清FOXQ1(6.48±2.16 ng/ml,11.21±3.74 ng/ml vs 0.52±0.17ng/ml)和CEACAM19(54.93±13.75 ng/L,87.17±21.80 ng/L vs 31.29±7.82 ng/L)水平升高,差异有统计学意义(t=30.133,31.279;16.371,26.431,均P <0.05);与CIN组比较,宫颈癌组血清FOXQ1和CEACAM19水平升高,差异有统计学意义(t=11.997,13.703,均P <0.05)。与高分化比较,低、中分化的宫颈癌患者血清FOXQ1(14.56±4.85 ng/ml vs 7.38±2.46 ng/ml),CEACAM19(96.87±32.29 ng/L vs 76.08±25.36 ng/L)水平升高,差异有统计学意义(t=10.415,3.945,均P <0.05)。血清FOXQ1,CEACAM19诊断宫颈癌的曲线下面积(area under curve, AUC)分别为0.878,0.887,FOXQ1和CEACAM19联合诊断宫颈癌的AUC为0.942,其敏感度和特异度分别为86.7%,92.1%。血清FOXQ1和CEACAM19水平升高与宫颈癌发生相关[OR (95%CI)=2.435(1.545~3.837),2.382(1.563~3.630),P=0.003]。结论宫颈癌患者血清FOXQ1和CEACAM19水平较高,二者联合检测有助于宫颈癌的早期诊断及临床筛查。Objective To investigate the value of combined detection of serum fork-head box Q1(FOXQ1)and carcinoembryonic antigen-related cell adhesion molecule 19(CEACAM19)in the early diagnosis of cervical cancer.Methods A total of 120 patients with cervical cancer and 120 patients with cervical intraepithelial neoplasias(CIN)treated in Jingzhou Central Hospital from January 2019 to August 2022 were selected as cervical cancer group and CIN group respectively,and 120 healthy people were selected as healthy group in the same period.The levels of serum FOXQ1 and CEACAM19 in cervical cancer group,CIN group and healthy group were compared.The relationship between serum FOXQ1,CEACAM19 levels and clinicopathological characteristics of cervical cancer was analyzed.Receiver operating characteristic(ROC)curve analysis was used to analyze the value of serum FOXQ1 and CEACAM19 in early diagnosis of cervical cancer,and Logistic regression analysis was used to analyze the influencing factors of cervical cancer.Results Compared with the healthy group,the serum FOXQ1(6.48±2.16 ng/ml,11.21±3.74 ng/ml vs 0.52±0.17 ng/ml)and CEACAM19(54.93±13.75 ng/L,87.17±21.80 ng/L vs 31.29±7.82 ng/L)levels in CIN group and cervical cancer group were significantly higher,and the differences were statistically significant(t=30.133,31.279;16.371,26.431,all P<0.05).Compared with CIN group,the levels of serum FOXQ1 and CEACAM19 in cervical cancer group were significantly higher,the differences were statistically significant(t=11.997,13.703,all P<0.05).Compared with well differentiated cervical cancer patients,the levels of serum FOXQ1(14.56±4.85 ng/ml vs 7.38±2.46 ng/ml)and CEACAM19(96.87±32.29 ng/L vs 76.08±25.36 ng/L)in patients with poorly and moderately differentiated cervical cancer were significantly higher,and the differences were statistically significant(t=10.415,3.945,all P<0.05).The area under curve(AUC)of serum FOXQ1 and CEACAM19 in the diagnosis of cervical cancer was 0.878 and 0.887,respectively,the AUC of FOXQ1 combined CEACAM19 in th

关 键 词：宫颈癌 叉头框蛋白 癌胚抗原相关细胞黏附分子19 早期诊断 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]